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. 2022 Aug;45(4):649-657.
doi: 10.1007/s10865-022-00307-4. Epub 2022 Apr 8.

Discrimination is associated with C-reactive protein among young sexual minority men

Stephanie H Cook  1   2   3 , Natalie Slopen  4 , Laura Scarimbolo  5 , Nicholas Mirin  5 , Erica P Wood  5 , Nicole Rosendale  6   7 , Rumi Chunara  8   9 , Colin W Burke  10 , Perry N Halkitis  11   12   13   14   15
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Discrimination is associated with C-reactive protein among young sexual minority men

Stephanie H Cook et al. J Behav Med. 2022 Aug.

Abstract

This report examines associations between everyday discrimination, microaggressions, and CRP to gain insight on potential mechanisms that may underlie increased CVD risk among sexual minority male young adults. The sample consisted of 60 participants taken from the P18 cohort between the ages of 24 and 28 years. Multinomial logistic regression models were used to examine the association between perceived everyday discrimination and LGBQ microaggressions with C-reactive protein cardiovascular risk categories of low-, average-, and high-risk, as defined by the American Heart Association and Centers for Disease Control. Adjustments were made for BMI. Individuals who experienced more everyday discrimination had a higher risk of being classified in the high-risk CRP group compared to the low-risk CRP group (RRR = 3.35, p = 0.02). Interpersonal LGBQ microaggressions were not associated with CRP risk category. Everyday discrimination, but not specific microaggressions based on sexual orientation, were associated with elevated levels of CRP among young sexual minority men (YSMM). Thus, to implement culturally and age-appropriate interventions, further researcher is needed to critically examine the specific types of discrimination and the resultant impact on YSMM's health.

Keywords: C-reactive protein (CRP); Discrimination; Microaggressions; Sexual minority men.

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References

    1. Albert Michelle, A., & Ridker Paul, M. (2006). C-reactive protein as a risk predictor. Circulation, 114, e67–e74. https://doi.org/10.1161/CIRCULATIONAHA.106.613570 - DOI - PubMed
    1. Ballantyne Christie, M., Hoogeveen Ron, C., Bang, H., Coresh, J., Folsom Aaron, R., Heiss, G., & Sharrett, A. R. (2004). Lipoprotein-associated phospholipase A2, high-sensitivity c-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the atherosclerosis risk in communities (ARIC) study. Circulation, 109, 837–842. https://doi.org/10.1161/01.CIR.0000116763.91992.F1 - DOI - PubMed
    1. Bowleg, L. (2012). The problem with the phrase women and minorities: Intersectionality—An important theoretical framework for public health. American Journal of Public Health, 102, 1267–1273. - DOI
    1. Brindle, E., Fujita, M., Shofer, J., & O’Connor, K. A. (2010). Serum, plasma, and dried blood spot high-sensitivity C-reactive protein enzyme immunoassay for population research. Journal of Immunological Methods, 362, 112–120. https://doi.org/10.1016/j.jim.2010.09.014 - DOI - PubMed - PMC
    1. Caceres, B. A., Brody, A., Luscombe, R. E., Primiano, J. E., Marusca, P., Sitts, E. M., & Chyun, D. (2017). A systematic review of cardiovascular disease in sexual minorities. American Journal of Public Health, 107, e13–e21. https://doi.org/10.2105/AJPH.2016.303630 - DOI - PubMed - PMC

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