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Review
. 2022 Jun;40(3):884-891.
doi: 10.1007/s12640-022-00505-7. Epub 2022 Apr 8.

Tet Enzymes-Mediated DNA 5hmC Modification in Cerebral Ischemic and Hemorrhagic Injury

Xiaohua Ma #  1   2 , Bo Yang #  3 , Xiaojing Li  4 , Zhigang Miao  5   6
Affiliations
Review

Tet Enzymes-Mediated DNA 5hmC Modification in Cerebral Ischemic and Hemorrhagic Injury

Xiaohua Ma et al. Neurotox Res. 2022 Jun.

Abstract

5-Hydroxymethylcytosine (5hmC) has recently been found that plays an important role in many diseases; however, there are still few studies in the field of stroke. The purpose of this review is to introduce the influence and function of 5hmC in stroke, in order for more people can study it. In this review, we introduced the role of 5hmC in ischemia and hemorrhage stroke, and summarized the possible therapeutic prospects of 5hmC in stroke. In conclusion, we suggest that 5hmC may serve as a biomarker or therapeutic target for the treatment of stroke.

Keywords: 5-Hydroxymethylcytosine; Methylation; Stroke; Tet.

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