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Comment
. 2022 Jun;111(6):1195-1196.
doi: 10.1002/cpt.2579. Epub 2022 Apr 8.

Lorlatinib Exposed: A Far From Optimal Dose

Garth W Strohbehn  1   2   3 , Mark J Ratain  4   5   6
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Free article
Comment

Lorlatinib Exposed: A Far From Optimal Dose

Garth W Strohbehn et al. Clin Pharmacol Ther. 2022 Jun.
Free article
No abstract available

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References

    1. Chen, J. et al. Lorlatinib exposure-response analyses for safety and efficacy in a phase I/II trial to support benefit-risk assessment in non-small cell lung cancer. Clin. Pharmacol. Ther. 110, 1273-1281 (2021).
    1. Pascual, I. et al. Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: cohort analysis of 1457 patients. Pancreatology 19, 623-629 (2019).
    1. Camidge, D.R. Lorlatinib should not be considered as the preferred first-line option in patients with advanced ALK rearranged NSCLC. J. Thorac. Oncol. 16, 528-531 (2021).
    1. Ratain, M.J., Tannock, I.F. & Lichter, A.S. Dose optimization of sotorasib: is the US Food and Drug Administration Sending a Message? J. Clin. Oncol. 39, 3423-3426 (2021).
    1. Friends of Cancer Research. Optimizing Dosing in Oncology Drug Development: A Friends of Cancer Research White Paper (Friends of Cancer Research, Washington, DC, 2021).