Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

doi:10.1093/jpids/piac016

. 2022 Jun 22;11(6):300-302.

doi: 10.1093/jpids/piac016.

Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

Affiliations

¹ Department of Pathological Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.
² School of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
³ Infectious Diseases and Immunology, Miriam Hospital, Providence, Rhode Island, USA.
⁴ Lviv Regional Pathoanatomical Bureau, Lviv, Ukraine.
⁵ Department of Paediatric and Adolescent Diseases, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
⁶ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
⁷ Division of Pediatric Infectious Diseases, Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁸ Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.
⁹ Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
¹⁰ Department of Tuberculosis and Pulmonology, Bogomolets National Medical University, Kyiv, Ukraine.

PMID: 35395086
PMCID: PMC9214781
DOI: 10.1093/jpids/piac016

Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

Petro V Kuzyk et al. J Pediatric Infect Dis Soc. 2022.

. 2022 Jun 22;11(6):300-302.

doi: 10.1093/jpids/piac016.

Authors

Affiliations

¹ Department of Pathological Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.
² School of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
³ Infectious Diseases and Immunology, Miriam Hospital, Providence, Rhode Island, USA.
⁴ Lviv Regional Pathoanatomical Bureau, Lviv, Ukraine.
⁵ Department of Paediatric and Adolescent Diseases, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
⁶ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
⁷ Division of Pediatric Infectious Diseases, Department of Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁸ Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.
⁹ Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
¹⁰ Department of Tuberculosis and Pulmonology, Bogomolets National Medical University, Kyiv, Ukraine.

PMID: 35395086
PMCID: PMC9214781
DOI: 10.1093/jpids/piac016

Abstract

We reviewed autopsy data from general hospitals in Lviv, Ukraine to understand pediatric mortality due to tuberculosis (TB). We identified 14 (0.6%) of 2345 autopsied children with unrecognized or untreated TB. More sensitive TB diagnostics for children and improved strategies for identifying which children require TB evaluation are urgently needed.

Keywords: diagnostics; meningitis; postmortem; tuberculosis.

© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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References

1. Dodd PJ, Yuen CM, Sismanidis C, Seddon JA, Jenkins HE. The global burden of tuberculosis mortality in children: a mathematical modelling study. Lancet Glob Health 2017; 5:e898–906. - PMC - PubMed
1. World Health Organization. Global Tuberculosis Report. 2021. Accessed November 16, 2021. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa...
1. Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med 2012; 367:348–61. - PubMed
1. World Bank. Proportion of the population aged <15 years old in 2020. Accessed February 15, 2022.https://databank.worldbank.org/source/health-nutrition-and-population-st...
1. Jenkins HE, Yuen CM, Rodriguez CA, et al. . Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2017; 17:285–95. - PMC - PubMed

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[1] Dodd PJ, Yuen CM, Sismanidis C, Seddon JA, Jenkins HE. The global burden of tuberculosis mortality in children: a mathematical modelling study. Lancet Glob Health 2017; 5:e898–906. - PMC - PubMed

[2] Dodd PJ, Yuen CM, Sismanidis C, Seddon JA, Jenkins HE. The global burden of tuberculosis mortality in children: a mathematical modelling study. Lancet Glob Health 2017; 5:e898–906. - PMC - PubMed

[3] World Health Organization. Global Tuberculosis Report. 2021. Accessed November 16, 2021. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa...

[4] World Health Organization. Global Tuberculosis Report. 2021. Accessed November 16, 2021. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa...

[5] Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med 2012; 367:348–61. - PubMed

[6] Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med 2012; 367:348–61. - PubMed

[7] World Bank. Proportion of the population aged <15 years old in 2020. Accessed February 15, 2022.https://databank.worldbank.org/source/health-nutrition-and-population-st...

[8] World Bank. Proportion of the population aged <15 years old in 2020. Accessed February 15, 2022.https://databank.worldbank.org/source/health-nutrition-and-population-st...

[9] Jenkins HE, Yuen CM, Rodriguez CA, et al. . Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2017; 17:285–95. - PMC - PubMed

[10] Jenkins HE, Yuen CM, Rodriguez CA, et al. . Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2017; 17:285–95. - PMC - PubMed

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Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

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Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

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