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Comment
. 2022 Apr 8;26(1):100.
doi: 10.1186/s13054-022-03953-x.

Pancreatic stone protein as a biomarker of sepsis

Diogo Lopes  1 , Beatriz Chumbinho  2 , João Pedro Bandovas  2 , Pedro Faria  3 , Catarina Espírito Santo  3 , Bernardo Ferreira  3 , Luis Val-Flores  3 , Rui Pereira  3 , Nuno Germano  3 , Luís Bento  4   5
Affiliations
Comment

Pancreatic stone protein as a biomarker of sepsis

Diogo Lopes et al. Crit Care. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

We are currently conducting an observational prospective trial using this biomarker, without any financial funding from PSP developer (Abionic®).

Figures

Fig. 1
Fig. 1
PSP/reg1 and sepsis. A Distribution of PSP/reg1 in a healthy human digestive system and the deposition in the brain of Alzheimer's disease patients. B Hypothetical model of PSP's involvement in sepsis. Sepsis triggers an imbalance of the host immune response triggering cell or organ dysfunction, increasing the PSP/reg 1 in the serum of the septic patients. Amyloid-beta (Aβ), neurofibrillary tangles (NFL), pancreatic stone protein (PSP)
See this image and copyright information in PMC

Comment on

References

    1. Barichello T, Generoso J, Singer M, Dal-Pizzol F. Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review. Crit Care. 2022;26:14. doi: 10.1186/s13054-021-03862-5. - DOI - PMC - PubMed
    1. Klein H, Niggemann P, Buehler P, et al. Pancreatic stone protein predicts sepsis in severely burned patients irrespective of trauma severity. Ann Surg. 2021;274(6):e1179–e1186. doi: 10.1097/SLA.0000000000003784. - DOI - PubMed
    1. Pugin J, Daix T, Pagani JL, et al. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study. Crit Care. 2021;25:151. doi: 10.1186/s13054-021-03576-8. - DOI - PMC - PubMed
    1. Prazak J, Irincheeva I, Llewelyn M, et al. Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis. Crit Care. 2021;25:182. doi: 10.1186/s13054-021-03609-2. - DOI - PMC - PubMed
    1. Van Singer M, Brahier T, Brochu Vez MJ, et al. Pancreatic stone protein for early mortality prediction in COVID-19 patients. Crit Care. 2021;25:267. doi: 10.1186/s13054-021-03704-4. - DOI - PMC - PubMed