Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 May;33(5):875-878.
doi: 10.1681/ASN.2022030309. Epub 2022 Apr 8.

A View on Cathepsin C as a Target for Therapy in AAV

Affiliations
Editorial

A View on Cathepsin C as a Target for Therapy in AAV

Renate Kain et al. J Am Soc Nephrol. 2022 May.
No abstract available

Keywords: ANCA; cathepsin C; neutrophil serine proteases; proteinase 3; vasculitis.

PubMed Disclaimer

Comment on

  • Targeting Cathepsin C in PR3-ANCA Vasculitis.
    Jerke U, Eulenberg-Gustavus C, Rousselle A, Nicklin P, Kreideweiss S, Grundl MA, Eickholz P, Nickles K, Schreiber A, Korkmaz B, Kettritz R. Jerke U, et al. J Am Soc Nephrol. 2022 May;33(5):936-947. doi: 10.1681/ASN.2021081112. Epub 2022 Mar 15. J Am Soc Nephrol. 2022. PMID: 35292437 Free PMC article.

References

    1. Kos J, Mitrović A, Perišić Nanut M, Pišlar A: Lysosomal peptidases-intriguing roles in cancer progression and neurodegeneration [published online ahead of print January 23, 2022]. FEBS Open Bio 10.1002/2211-5463.13372 - DOI - PMC - PubMed
    1. Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, et al. : Therapeutic targeting of cathepsin C: From pathophysiology to treatment. Pharmacol Ther 190: 202–236, 2018 - PubMed
    1. Seren S, Rashed Abouzaid M, Eulenberg-Gustavus C, Hirschfeld J, Nasr Soliman H, Jerke U, et al. : Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. J Biol Chem 293: 12415–12428, 2018 - PMC - PubMed
    1. Korkmaz B, Lesner A, Marchand-Adam S, Moss C, Jenne DE: Lung protection by cathepsin C inhibition: A new hope for COVID-19 and ARDS? J Med Chem 63: 13258–13265, 2020 - PubMed
    1. Shen XB, Chen X, Zhang ZY, Wu FF, Liu XH: Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities. Eur J Med Chem 225: 113818, 2021 - PubMed

LinkOut - more resources