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Review
. 2022 Aug;269(8):4560-4563.
doi: 10.1007/s00415-022-11117-8. Epub 2022 Apr 8.

Fulminant cerebral edema following CAR T-cell therapy: case report and pathophysiological insights from literature review

Umberto Pensato #  1   2   3 , Lorenzo Muccioli #  1   3 , Pierluigi Zinzani  4   5   3 , Roberto D'Angelo  6   3 , Elisabetta Pierucci  5   3 , Beatrice Casadei  4   5   3 , Michele Dicataldo  5   3 , Serena De Matteis  5   3 , Pietro Cortelli  1   6   3 , Francesca Bonifazi #  5   3 , Maria Guarino #  7   8
Affiliations
Review

Fulminant cerebral edema following CAR T-cell therapy: case report and pathophysiological insights from literature review

Umberto Pensato et al. J Neurol. 2022 Aug.

Erratum in

No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Head CT signs of diffuse cerebral edema. Axial non-contrast-enhanced head computer tomography (CT) shows diffuse brain swelling predominantly involving infra-tentorial brain structures, associated with effacement of sulci and ventricles and decreased gray–white matter differentiation. The brainstem appears hypo-attenuated compared to other infra-tentorial brain structures
See this image and copyright information in PMC

References

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    1. Lee DW, Santomasso BD, Locke FL, et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biol Blood Marrow Transplant. 2019;25:625–638. doi: 10.1016/j.bbmt.2018.12.758. - DOI - PubMed
    1. Pensato U, Amore G, D'Angelo R, et al. Frontal predominant encephalopathy with early paligraphia as a distinctive signature of CAR T-cell therapy-related neurotoxicity. J Neurol. 2022;269:609–615. doi: 10.1007/s00415-021-10766-5. - DOI - PMC - PubMed
    1. Gust J, Finney OC, Li D, et al. Glial injury in neurotoxicity after pediatric CD19-directed chimeric antigen receptor T cell therapy. Ann Neurol. 2019;86:42–54. - PMC - PubMed
    1. Torre M, Solomon IH, Sutherland CL, et al. Neuropathology of a case with fatal CAR T-cell-associated cerebral edema. J Neuropathol Exp Neurol. 2018;77:877–882. doi: 10.1093/jnen/nly064. - DOI - PubMed

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