Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Nov;114(3):769-89.
doi: 10.1093/genetics/114.3.769.

Repression of meiotic crossing over by a centromere (CEN3) in Saccharomyces cerevisiae

E J Lambie, G S Roeder

Repression of meiotic crossing over by a centromere (CEN3) in Saccharomyces cerevisiae

E J Lambie et al. Genetics. 1986 Nov.

Abstract

The location of the centromere of chromosome III (CEN3) of Saccharomyces cerevisiae has been altered by means of transformation. The frequency of meiotic crossing over in the CEN3-PGK1 and LEU2-CEN3 intervals increases approximately 1.5- and fourfold, respectively, when CEN3 is repositioned at HIS4. The centromere-distal HIS4-LEU2 region experiences a three- to fivefold decrease in the frequency of meiotic exchange when CEN3 is repositioned at HIS4. The inhibition of meiotic crossing over is conferred by a 627-base-pair fragment of CEN3 DNA and is not dependent on the orientation of CEN3 relative to the rest of chromosome III.

PubMed Disclaimer

References

    1. Genetics. 1956 Jul;41(4):623-30 - PubMed
    1. Gene. 1982 Apr;18(1):47-59 - PubMed
    1. Genetics. 1956 Jul;41(4):610-22 - PubMed
    1. Gene. 1977;2(2):75-93 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Jan;76(1):368-72 - PubMed

Publication types