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Review
. 2022 Jun;193(2):281-291.
doi: 10.1007/s10549-022-06575-7. Epub 2022 Apr 9.

Clinical trial data and emerging strategies: HER2-positive breast cancer

Sonia Pernas  1   2 , Sara M Tolaney  3   4
Affiliations
Review

Clinical trial data and emerging strategies: HER2-positive breast cancer

Sonia Pernas et al. Breast Cancer Res Treat. 2022 Jun.

Abstract

A deeper insight into tumor biology and HER2 signaling has led to the development of novel anti-HER2 drugs that have significantly improved the prognosis of patients with HER2-positive breast cancer. The breast cancer immune microenvironment has emerged as a potential prognostic factor. Moreover, the host immune system not only seems to play a critical role in the prognosis of HER2-positive breast cancer, but also seems to modulate treatment response to some HER2-targeted agents. Here, we review the latest evidence of the role of immunotherapy in HER2-positive breast cancer and present emerging strategies.

Keywords: Antibody-dependent cellular cytotoxicity; HER2-positive breast cancer; Immune checkpoints; Immunotherapy; Tumor immune microenvironment; Tumor-infiltrating lymphocytes.

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References

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