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Review
. 2022 Jun;76(3):575-583.
doi: 10.1007/s11418-022-01622-5. Epub 2022 Apr 10.

Marine natural products that inhibit osteoclastogenesis and promote osteoblast differentiation

Ahmed H H El-Desoky  1   2 , Sachiko Tsukamoto  3
Affiliations
Review

Marine natural products that inhibit osteoclastogenesis and promote osteoblast differentiation

Ahmed H H El-Desoky et al. J Nat Med. 2022 Jun.

Abstract

Osteoporosis is a disease that affects the quality of life of elderly people. The balance between bone formation mediated by osteoblasts and bone resorption by osteoclasts is important to maintain the normal bone condition. Therefore, the promotion of osteoblast differentiation and the suppression of osteoclastogenesis are effective strategies for osteoporosis treatment. Marine organisms are a promising source of biologically active and structurally diverse secondary metabolites, and have been providing drug leads for the treatment of numerous diseases. We describe the marine-derived secondary metabolites that can inhibit receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and promote osteoblast differentiation.

Keywords: Marine organisms; Osteoblast; Osteoclast; Osteoporosis; RANKL; TRAP.

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Figures

Fig. 1
Fig. 1
RANKL-induced osteoclastogenesis and bone resorption
Fig. 2
Fig. 2
Structures of compounds that inhibited RANKL-induced osteoclastogenesis isolated from cyanobacteria
Fig. 3
Fig. 3
Structures of compounds that inhibited RANKL-induced osteoclastogenesis isolated from a bacterium
Fig. 4
Fig. 4
Structures of compounds that inhibited RANKL-induced osteoclastogenesis isolated from fungi
Fig. 5
Fig. 5
Structures of a compound that inhibited RANKL-induced osteoclastogenesis isolated from a dinoflagellate
Fig. 6
Fig. 6
Structures of compounds that inhibited RANKL-induced osteoclastogenesis isolated from algae
Fig. 7
Fig. 7
Structures of compounds that inhibited RANKL-induced osteoclastogenesis isolated from sponges
Fig. 8
Fig. 8
Structures of compounds that induced osteoblast differentiation
See this image and copyright information in PMC

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