Methylglyoxal in beverages and foods: its mutagenicity and carcinogenicity
- PMID: 3539787
Item in Clipboard
Methylglyoxal in beverages and foods: its mutagenicity and carcinogenicity
IARC Sci Publ.
1986.
Abstract
Methylglyoxal was found to induce mutations in Salmonella typhimurium strains TA100, TA102 and TA104, gene conversion in Saccharomyces cerevisiae strain D7, and diphtheria toxin resistance mutation in Chinese hamster lung cells. Methylglyoxal was detected in coffee, whiskey, a soft drink, toasted bread and soy sauce. The mutagenicity of methylglyoxal was suppressed by sulfite, cysteine, glutathione and dithiothreitol, and enhanced by hydrogen peroxide. Methylglyoxal induced sarcomas in rats at the site of its subcutaneous injection.
Similar articles
-
Mutagenicity studies on coffee. The influence of different factors on the mutagenic activity in the Salmonella/mammalian microsome assay.Mutat Res. 1985 Apr-May;156(1-2):39-52. doi: 10.1016/0165-1218(85)90005-9. Mutat Res. 1985. PMID: 3889626
-
Implication of hydrogen peroxide in the mutagenicity of coffee.Mutat Res. 1985 Dec;144(4):227-30. doi: 10.1016/0165-7992(85)90055-7. Mutat Res. 1985. PMID: 3906385
-
Mutagenicity of methylglyoxal in coffee.Gan. 1982 Oct;73(5):681-3. Gan. 1982. PMID: 6762317
-
Bacterial mutagenicity of natural materials, pyrolysis products and additives in foodstuffs and their association with genotoxic effects in mammals.Dev Toxicol Environ Sci. 1983;11:115-33. Dev Toxicol Environ Sci. 1983. PMID: 6376055 Review. No abstract available.
-
NTP Technical Report on the metabolism, toxicity and predicted carcinogenicity of diazoaminobenzene (CAS No. 136-35-6).Toxic Rep Ser. 2002 Sep;(73):1-23, A1-C6. Toxic Rep Ser. 2002. PMID: 12370695 Review.
Cited by
-
Importance of RpoS and Dps in survival of exposure of both exponential- and stationary-phase Escherichia coli cells to the electrophile N-ethylmaleimide.J Bacteriol. 1998 Mar;180(5):1030-6. doi: 10.1128/JB.180.5.1030-1036.1998. J Bacteriol. 1998. PMID: 9495739 Free PMC article.
-
Stereospecific synthesis and characterization of oligodeoxyribonucleotides containing an N2-(1-carboxyethyl)-2'-deoxyguanosine.J Am Chem Soc. 2007 Oct 10;129(40):12123-30. doi: 10.1021/ja072130e. Epub 2007 Sep 18. J Am Chem Soc. 2007. PMID: 17877341 Free PMC article.
-
Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability.Hum Mol Genet. 2011 Jun 15;20(12):2322-32. doi: 10.1093/hmg/ddr125. Epub 2011 Apr 12. Hum Mol Genet. 2011. PMID: 21487022 Free PMC article.
-
Glycation free adduct accumulation in renal disease: the new AGE.Pediatr Nephrol. 2005 Nov;20(11):1515-22. doi: 10.1007/s00467-005-2011-9. Epub 2005 Aug 24. Pediatr Nephrol. 2005. PMID: 16133053 Review.
-
Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients. 2019 Mar 24;11(3):694. doi: 10.3390/nu11030694. Nutrients. 2019. PMID: 30909640 Free PMC article.