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. 2022 Jul;38(7):641-645.
doi: 10.1016/j.tig.2022.03.008. Epub 2022 Apr 6.

Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery

Thomas M Guérin  1 , Stéphane Marcand  2
Affiliations

Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery

Thomas M Guérin et al. Trends Genet. 2022 Jul.

Abstract

2021 marked the 80th anniversary of Barbara McClintock's pioneering article on the breakage-fusion-bridge (BFB) cycle. Of the three steps of the BFB cycle, breakage remains the least understood despite its major contribution to mutagenesis. We discuss recent findings shedding light on how chromatin bridges break in yeast and animal cells.

Keywords: chromosome; cytokinesis; dicentric; genome instability; oncogenesis; telomere.

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Conflict of interest statement

Declaration of interests No interests are declared.

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