Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug;40(3):320-331.
doi: 10.1002/hon.3002. Epub 2022 Apr 18.

Host-related factors and cancer: Malnutrition and non-Hodgkin lymphoma

Salvatrice Mancuso  1 , Marta Mattana  2 , Marco Santoro  1 , Melania Carlisi  2 , Silvio Buscemi  1 , Sergio Siragusa  1
Affiliations
Review

Host-related factors and cancer: Malnutrition and non-Hodgkin lymphoma

Salvatrice Mancuso et al. Hematol Oncol. 2022 Aug.

Abstract

Assessment of host-related factors is a crucial aspect in the comprehensive management of cancer patients. A distinct nutritional disturbance linked to cancer has been recognized to be associated with negative outcomes. However, compared to solid tumors, only a limited number of studies have looked specifically at nutritional issues in the field of lymphoma. The aim of this review is to integrate the current knowledge on interactions between malnutrition and lymphoma and address most relevant and pertinent questions. We first provide a literature review on the mutual biological relationship between malnutrition and lymphoma. Next, we explore the overlap between malnutrition, sarcopenia, cachexia and frailty in lymphoma studies. In addition, we summarize the clinical assessment scales used to measure malnutrition in lymphoma subjects. Furthermore, we address the problem of nutritional interventions aimed at patients who are candidates for treatment for lymphoma. Malnutrition can arise as a consequence of lymphoma disease and can in turn promote lymphomagenesis, negatively affect the response to therapy and favor adverse event to treatment. There is increasing evidence that malnutrition, sarcopenia and cachexia in lymphoma are intimately inter-related and are a hallmark of frailty. A variety of different tools are recorded with the apparent ability to describe nutritional status and to impact prognosis in lymphoma patients. Finally, a network of prognostic host- and disease-related factors is proposed where malnutrition can interact with each other in complex ways.

Keywords: cancer metabolic syndrome; diffuse large B-cell lymphoma; frailty; non-Hodgkin lymphoma; nutritional status.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant financial or non‐financial interests to disclose.

Figures

FIGURE 1
FIGURE 1
DLBCL, Diffuse Large B‐ cell Lymphoma; ABC‐DLBCL, Activated B‐Cell Like DLBCL; GCB‐DLBCL, Germinal Center B‐Cell Like DLBCL; HGBL‐DH/TH, High Grade Lymphoma‐ Double Hit/Triple Hit
See this image and copyright information in PMC

References

    1. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS. Lymphoma incidence patterns by WHO subtype in the United States, 1992‐2001. Blood. 2006;107(1):265‐276. - PMC - PubMed
    1. National Cancer Institute . Cancer Stat Facts: NHL—Diffuse Large B‐cell Lymphoma (DLBCL); 2020. https://seer.cancer.gov/statfacts/html/dlbcl.html
    1. Di M, Huntington SF, Olszewski AJ. Challenges and opportunities in the management of diffuse large B‐cell lymphoma in older patients. Oncol. 2021;26(2):120‐132. - PMC - PubMed
    1. Krok‐Schoen JL, Fisher JL, Stephens JA, et al. Incidence and survival of hematological cancers among adults ages ≥75 years. Cancer Med. 2018;7(7):3425‐3433. - PMC - PubMed
    1. Coiffier B, Sarkozy C. Diffuse large B‐cell lymphoma: R‐CHOP failure—what to do? Am Soc Hematol Educ Program. 2016;(1):366‐378. - PMC - PubMed

MeSH terms