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. 2022 Mar 22;14(1):9264.
doi: 10.4081/dr.2022.9264. eCollection 2022 Mar 11.

Keratolysis exfoliativa-like eruption induced by ranolazine

Elena Pierobon  1 , Lerica Germi  2 , Andrea Sechi  2 , Giampaolo Trevisan  2 , Elena Pezzolo  2 , Claudio Feliciani  1 , Luigi Naldi  2
Affiliations

Keratolysis exfoliativa-like eruption induced by ranolazine

Elena Pierobon et al. Dermatol Reports. .

Abstract

Dermatoses affecting palms may represent a dermatologic challenge from both the diagnostic, and therapeutic point of view. Patients with supposedly occupational dermatitis can spend months or even years in a frustrating attempt to avoid contact with possible irritants or allergens. To underline the importance of a thorough unbiased analysis of the patient's history and clinical features, we present the iconic case of a bricklayer affected by a chronic, disabling desquamation of palms which in the end was classified as keratolysis exfoliativa (KE) attributed to ranolazine-intake, an antianginal drug. To the best of our knowledge, this specific adverse effect of druginduced KE of palms has never been reported before in association with ranolazine.

Keywords: Cutaneous drug reaction; Hand dermatititis; Keratolysis exfoliativa; Ranolazine.

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Conflict of interest statement

Conflict of interest: The authors declare no potential conflict of interest.

Figures

Figure 1.
Figure 1.
Exfoliative dermatitis of the palms characterized by expanding collarettes of focal peeling of the stratum corneum.
Figure 2.
Figure 2.
Complete restitutio ad integrum after suspension of cardiologic therapy with ranolazine.
See this image and copyright information in PMC

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