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. 2022 Feb 14;3(2):zqac004.
doi: 10.1093/function/zqac004. eCollection 2022.

Electrophysiological Experiments Revalidate the Two-ion Theory of Energy Coupling and ATP Synthesis

Sunil Nath  1
Affiliations

Electrophysiological Experiments Revalidate the Two-ion Theory of Energy Coupling and ATP Synthesis

Sunil Nath. Function (Oxf). .
No abstract available

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Figures

Figure 1.
Figure 1.
Concept of energy coupling in OXPHOS at the physiological level. The diagram illustrates the coupling in Complexes I – V according to Mitchell's one-ion chemiosmotic theory (A), and Nath's two-ion theory, where the second ion is a dicarboxylic acid anion, , (B), or a counter-cation such as K+ or Na+,, , shown as C+ in panel C. Primary ion translocations are denoted by bold arrows, and secondary ion translocations by dashed arrows. The part of the two-ion theory related to FOF1-ATP synthase (Complex V) revalidated by the recent electrophysiological experiments of Juhaszova et al. is highlighted in blue, while aspects of the two-ion theory related to Complex I validated experimentally by Zemel et al. are shown in green.
See this image and copyright information in PMC

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References

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