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Review
. 2022 Mar 14;13(6):1713-1724.
doi: 10.7150/jca.70550. eCollection 2022.

Cytokeratin Expression Pattern in Human Endometrial Carcinomas and Lymph Nodes Micrometastasis: a Mini-review

Danuta Vasilevska  1 , Vilius Rudaitis  2 , Aneta Adamiak-Godlewska  3 , Anna Semczuk-Sikora  4 , Dorota Lewkowicz  5 , Dominika Vasilevska  2 , Andrzej Semczuk  3
Affiliations
Review

Cytokeratin Expression Pattern in Human Endometrial Carcinomas and Lymph Nodes Micrometastasis: a Mini-review

Danuta Vasilevska et al. J Cancer. .

Abstract

Cytokeratins (CKs) are the largest subgroup of intermediate filament proteins, preferentially expressed in epithelial tissues. CKs play a critical role in determining epithelial structural integrity under stressful conditions in addition to their various fundamental functions in cellular proliferation, apoptosis, migration, adherence and molecular signaling. Immunohistochemical CKs staining could be evaluated with a proper comprehension of their task limitations and their association with the normal morphology to avoid misdiagnosis. Herein, we critically review the CKs expression patterns in ECs in relation to clinicopathological features and patients' outcome. We also briefly discussed the recent advantage of CKs immunohistochemical staining in the detection of EC micrometastasis.

Keywords: Cytokeratin; Endometrial Carcinomas; Lymph Node; Metastasis; OSNA..

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Chromosomal localization of selected types of human CKs .
Figure 2
Figure 2
A-B. The IF protein organization.
Figure 3
Figure 3
Comparison of the expression patterns of pankeratin and CK1/5/10/14 in ECs -.
Figure 4
Figure 4
Comparison of CK7 and CK20 expression in EC based on literature review , , -.
Figure 5
Figure 5
Comparison of CK5/6, CK14, CK8/18, CK19, and CK22 in ECs based on literature review , , .
See this image and copyright information in PMC

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