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. 2022 Jan 3;2(1):55-63.
doi: 10.21873/cdp.10076. eCollection 2022 Jan-Feb.

Immune-related Thyroid Dysfunction (irTD) in Non-small Cell Lung Cancer (NSCLC) Correlates With Response and Survival

Mario Giovanni Chilelli  1 , Carlo Signorelli  1 , Julio Rodrigo Giron Berrios  1 , Angelo Onorato  1 , Fabrizio Nelli  1 , Maria Agnese Fabbri  1 , Francesca Primi  1 , Eleonora Marrucci  1 , Antonella Virtuoso  1 , Marta Schirripa  1 , Marco Mazzotta  1 , Enzo Maria Ruggeri  1
Affiliations

Immune-related Thyroid Dysfunction (irTD) in Non-small Cell Lung Cancer (NSCLC) Correlates With Response and Survival

Mario Giovanni Chilelli et al. Cancer Diagn Progn. .

Abstract

Background: There is no clear information on the proportion of patients who need therapy for immune-related thyroid dysfunction (irTD) or who need to delay, omit, or discontinue immunotherapy. Furthermore, it is not well known whether irTD correlates with better outcomes or not.

Patients and methods: We conducted a retrospective study in patients with metastatic non-small cell lung cancer (NSCLC) treated with anti-PD1 or anti-PD-L1.

Results: Our study enrolled 75 patients, 25.3% of them developed immune-related thyroid dysfunction. Three patients delayed a course of immunotherapy due to irTD, 2 patients omitted a course and 1 patient permanently discontinued. In patients with irTD compared with those without irTD the ORR was 42.1% vs. 7.1% (p<0.001), DCR was 78.9% vs. 32.1% (p<0.001); mPFS was 15.7 vs. 3.6 months (p<0.001) and mOS was 18.6 months vs. 5.1 months (p<0.001).

Conclusion: Immune-related thyroid dysfunction has a mild impact on the immunotherapy treatment program. The occurrence of irTD correlates with more favorable response and survival.

Keywords: Non-small cell lung cancer; atezolizumab; checkpoint inhibitors; nivolumab; pembrolizumab; thyroid dysfunction.

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Conflict of interest statement

The Authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1. Kaplan-Meier estimates of progression-free survival for patients with or without immune-related thyroid dysfunction (irTD).
Figure 2
Figure 2. Kaplan-Meier estimates of overall survival for patients with or without immune-related thyroid dysfunction (irTD).
See this image and copyright information in PMC

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