Multicenter Study

. 2022 Mar 24:10:783153.

doi: 10.3389/fpubh.2022.783153. eCollection 2022.

The Incidence and Characteristics of Perinatal Stroke in Beijing: A Multicenter Study

Qianqian Xia¹, Zhao Yang¹, Yao Xie¹, Ying Zhu¹, Zixin Yang², Mingyan Hei², Yingxue Ding³, Weijing Kong³, Limin Kang⁴, Shengnan Yang⁴, Yabo Mei⁵, Zhichun Feng⁵, Li Zhang⁶, Yanzhe Lei⁶, Ping Wang⁷, Jingyu Dong⁸, Li Yang⁸, Jun Ju⁹, Hesheng Chang⁹, Shina Zhan¹⁰, Jinqian Yu¹⁰, Peng Zhang¹¹, Ran Wang¹¹, Hui Guo¹², Xinli Liu¹², Huaqing Tan¹³, Yakun Liu¹³, Zhenzong Zhang¹⁴, Lixia Zhen¹⁴, Jinting Yan¹⁵, Zhan Liu¹⁵, Chunxia Yang¹⁶, Qingqing Wang¹⁶, Jinfeng Wang¹⁷, Lifang Sun¹⁷, Huihui Zeng¹⁸, Jing Li¹⁸, Wenwen Qu¹⁹, Xuemei Wang^{19

20}, Guiying Liu²¹, Xi Yang²¹, Xinxin Liu²², Xuefeng Zhang²², Xiaojing Xu²³, Yanan Gu²³, Hui Long²⁴, Li Zhang²⁴, Lili Liu¹, Zezhong Tang¹, Xinlin Hou¹

Affiliations

¹ Pediatric Department, Peking University First Hospital, Beijing, China.
² Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
³ Beijing Friendship Hospital, Capital Medical University, Beijing, China.
⁴ Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
⁵ Neonatal Intensive Care Unit of Faculty of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
⁶ Pediatric Department, Haidian Maternal and Child Health Hospital, Beijing, China.
⁷ Department of Neonatology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
⁸ Pediatric Department, Tongzhou Maternal and Child Health Hospital, Beijing, China.
⁹ Pediatric Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
¹⁰ Pediatric Department, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing, China.
¹¹ Pediatric Department, Beijing Miyun Maternal and Child Health Hospital, Beijing, China.
¹² Pediatric Department, Fengtai Maternal and Child Health Hospital, Beijing, China.
¹³ Pediatric Department, Beijing Daxing Maternal and Child Care Hospital, Beijing, China.
¹⁴ Pediatric Department, The First Hospital of Fangshan, Beijing, China.
¹⁵ Pediatric Department, Beijing Mentougou Hospital, Beijing, China.
¹⁶ Pediatric Department, Changping Women and Children Health Care Hospital, Beijing, China.
¹⁷ Beijing Pinggu Maternal and Child Health Hospital, Beijing, China.
¹⁸ Pediatric Department, Huairou Maternal and Child Health Care Hospital, Beijing, China.
¹⁹ Department of Pediatrics, Peking University Shougang Hospital and Capital Medical University, Beijing, China.
²⁰ General Respiratory Department of Beijing Jingdu Children's Hospital, Beijing, China.
²¹ Department of Pediatrics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
²² Pediatric Department, Fifth Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
²³ Pediatric Department, The First Hospital of Tsinghua University, Beijing, China.
²⁴ Department of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

PMID: 35400054
PMCID: PMC8987304
DOI: 10.3389/fpubh.2022.783153

Multicenter Study

The Incidence and Characteristics of Perinatal Stroke in Beijing: A Multicenter Study

Qianqian Xia et al. Front Public Health. 2022.

. 2022 Mar 24:10:783153.

doi: 10.3389/fpubh.2022.783153. eCollection 2022.

Authors

Affiliations

¹ Pediatric Department, Peking University First Hospital, Beijing, China.
² Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
³ Beijing Friendship Hospital, Capital Medical University, Beijing, China.
⁴ Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
⁵ Neonatal Intensive Care Unit of Faculty of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
⁶ Pediatric Department, Haidian Maternal and Child Health Hospital, Beijing, China.
⁷ Department of Neonatology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
⁸ Pediatric Department, Tongzhou Maternal and Child Health Hospital, Beijing, China.
⁹ Pediatric Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
¹⁰ Pediatric Department, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing, China.
¹¹ Pediatric Department, Beijing Miyun Maternal and Child Health Hospital, Beijing, China.
¹² Pediatric Department, Fengtai Maternal and Child Health Hospital, Beijing, China.
¹³ Pediatric Department, Beijing Daxing Maternal and Child Care Hospital, Beijing, China.
¹⁴ Pediatric Department, The First Hospital of Fangshan, Beijing, China.
¹⁵ Pediatric Department, Beijing Mentougou Hospital, Beijing, China.
¹⁶ Pediatric Department, Changping Women and Children Health Care Hospital, Beijing, China.
¹⁷ Beijing Pinggu Maternal and Child Health Hospital, Beijing, China.
¹⁸ Pediatric Department, Huairou Maternal and Child Health Care Hospital, Beijing, China.
¹⁹ Department of Pediatrics, Peking University Shougang Hospital and Capital Medical University, Beijing, China.
²⁰ General Respiratory Department of Beijing Jingdu Children's Hospital, Beijing, China.
²¹ Department of Pediatrics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
²² Pediatric Department, Fifth Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
²³ Pediatric Department, The First Hospital of Tsinghua University, Beijing, China.
²⁴ Department of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

PMID: 35400054
PMCID: PMC8987304
DOI: 10.3389/fpubh.2022.783153

Abstract

Objective: To assess the incidence, risk factors, and clinical characteristics of perinatal stroke in Beijing.

Methods: This multicenter prospective study included all the live births from 17 representative maternal delivery hospitals in Beijing from March 1, 2019 to February 29, 2020. Neonates with a stroke were assigned to the study group. Clinical data, including general information, clinical manifestations, and risk factors, were collected. Up until 18 months after birth, neonates were routinely assessed according to the Ages and Stages Questionnaire (ASQ) and/or the Bayley scale. Statistical analysis was done using the chi-squared, t-tests, and logistic regression analysis using SPSS version 26.0.

Outcomes: In total, 27 cases were identified and the incidence of perinatal stroke in Beijing was 1/2,660 live births, including 1/5,985 for ischemic stroke and 1/4,788 for hemorrhagic stroke. Seventeen cases (62.96%) of acute symptomatic stroke and convulsions within 72 h (10 cases, 37.04%) were the most common presentations. Ten patients showed no neurological symptoms and were found to have had a stroke through routine cranial ultrasonography after being hospitalized for non-neurological diseases. The risk factors include primiparity, placental or uterine abruption/acute chorioamnionitis, intrauterine distress, asphyxia, and severe infection. In the study group, 11.1% (3/27) of patients had adverse neurodevelopmental outcomes. The patients in the study group had lower scores for the ASQ than those in the control group in the communication, gross, and fine motor dimensions.

Conclusion: The incidence of perinatal stroke in Beijing was consistent with that in other countries. Routine neuroimaging of infants with risk factors may enable identification of asymptomatic strokes in more patients. Patients who have suffered from a stroke may have neurological sequelae; therefore, early detection, treatment, and regular follow-ups are beneficial for improving their recovery outcomes.

Keywords: clinical characteristics; diagnosis; incidence; neonatal stroke; prognosis.

Copyright © 2022 Xia, Yang, Xie, Zhu, Yang, Hei, Ding, Kong, Kang, Yang, Mei, Feng, Zhang, Lei, Wang, Dong, Yang, Ju, Chang, Zhan, Yu, Zhang, Wang, Guo, Liu, Tan, Liu, Zhang, Zhen, Yan, Liu, Yang, Wang, Wang, Sun, Zeng, Li, Qu, Wang, Liu, Yang, Liu, Zhang, Xu, Gu, Long, Zhang, Liu, Tang and Hou.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a shared affiliation with several of the authors WQ and XW at time of review.

Figures

**Figure 1**
Case ascertainment methods. GA, gestational age; BD, birth date.

See this image and copyright information in PMC

References

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The Incidence and Characteristics of Perinatal Stroke in Beijing: A Multicenter Study

Affiliations

The Incidence and Characteristics of Perinatal Stroke in Beijing: A Multicenter Study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical