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. 2022 Feb;15(2):455-464.
doi: 10.14202/vetworld.2022.455-464. Epub 2022 Feb 25.

Seroprevalence of sheeppox and goatpox virus in Asia and African continent: A systematic review and meta-analysis (Scientometrics)

Kuralayanapalya Puttahonnappa Suresh  1 , Anenahalli Panduranga Bhavya  1 , Chandan Shivamallu  2 , Raghu Ram Achar  3 , Ekaterina Silina  4 , Victor Stupin  5 , Shiva Prasad Kollur  6 , Bibek Ranjan Shome  1 , Sharanagouda S Patil  1
Affiliations

Seroprevalence of sheeppox and goatpox virus in Asia and African continent: A systematic review and meta-analysis (Scientometrics)

Kuralayanapalya Puttahonnappa Suresh et al. Vet World. 2022 Feb.

Abstract

Background and aim: Two endemic capripox infectious diseases, sheeppox (SP) and goatpox (GP) are common in Asia, Africa, and the Middle East. Sheep and goats, in general, are considered current assets of small and marginal farmers and have significant economic value in terms of meat, wool, and skin/hide production. Sheep and goat populations in India total 148.88 million and 74.26 million, respectively. Capripox caused US$ 2.3 million (Indian Rupee [INR] 105 million) in economic damages in Maharashtra (India) alone, and it took over 6 years for a flock to recover from the outbreak. The projected yearly loss at the national level is US$ 27.47 million (INR 1250 million). As a result, Capripox diseases put small and marginal farmers under much financial strain. The present study estimates the seroprevalence of SP and GP diseases in the Asian and African continents using systematic review and meta-analysis. The results of the study will help researchers and policymakers to understand the spatial and temporal distribution of the disease and its burden. In addition, the results are also helpful to design and implement location-specific prevention and eradication measures against these diseases.

Materials and methods: Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines of Cochran collaborations were used for systematic review and subsequently meta-analysis were used. The literature was collected from various databases. Initial search string resulted in more than nine thousand articles for the period 2000 to 2020 using the different combinations of keywords and Boolean operators (or not) asterisk* and quotation marks. Out of 9398 papers, 80 studies were chosen for complete test reviews and quality bias evaluation using the inclusion and exclusion criteria. Finally, 21 articles were used for the meta-analysis. The statistical study employed fixed effects and random effects models using R.

Results: Seroprevalence of SP and GP was calculated using studies with a cumulative sample size of 4352, out of which sheep and goats' samples together contribute 48%, followed by sheep (32%) and goat (21%). The result of the meta-regression revealed that detection techniques had a significant impact on the overall effect size at 5% level (Qm=14.12). Subgroup analysis of polymerase chain reaction (PCR) test with samples was further grouped into two categories based on the median, and it revealed that 62% of samples used PCR as a detecting test followed by group-II.

Conclusion: From the study, it is concluded that SP and GP diseases are highly prevalent; hence, effective vaccines, proper education to farmers through extension activity, and transboundary disease movement restriction are necessary for the control and eradication of the disease.

Keywords: Africa; Asia; capripoxvirus; meta-analysis; seroprevalence; subgroup analysis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure-1
Figure-1
Schematic diagram of selection of articles used for the systematic review of this study.
Figure-2
Figure-2
Prevalence of sheeppox and goatpox in Asian and African continent [Source: Map was prepared by the authors].
Figure-3
Figure-3
Publication bias among studies is shown in funnel plot showing asymmetry and heterogeneity.
Figure-4
Figure-4
Forest plot for prevalence of sheeppox and goatpox in Asia and African continent based on test with samples.
Figure-5
Figure-5
Forest plot for the prevalence of sheeppox and goatpox in Asia and African continent based on region.
See this image and copyright information in PMC

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