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. 2022 Mar 30:2022:9484230.
doi: 10.1155/2022/9484230. eCollection 2022.

High Frequency Ultrasound-Based Evaluation of Clinical Effect of Ephedra-Forsythia-Red Bean Decoction Addition and Subtraction Treatment of Psoriasis Vulgaris

Yue Wang  1 , Hongju Lu  2 , Zhongzhu Hu  3
Affiliations

High Frequency Ultrasound-Based Evaluation of Clinical Effect of Ephedra-Forsythia-Red Bean Decoction Addition and Subtraction Treatment of Psoriasis Vulgaris

Yue Wang et al. Comput Intell Neurosci. .

Abstract

This study aimed to investigate the therapeutic effect of ephedra-forsythia-red bean decoction (a formula of traditional Chinese medicine) addition and subtraction treatment of psoriasis vulgaris based on 22 MHz high-frequency ultrasound, so as to provide reference for the selection of traditional Chinese medicine formulas for psoriasis and the clinical application of ultrasound. 80 patients with psoriasis vulgaris with exterior closing and internal depression syndrome diagnosed and treated in the hospital were divided into an observation group (40 cases) and a control group. Patients in the observation group were received ephedra-forsythia-red bean decoction addition and subtraction; and those in the control group were received traditional Chinese medicine of observation group subtraction of raw ephedra, cinnamomum cassia, addition of fineleaf schizonepeta herb, divaricate saposhnikovia root. 22 MHz high-frequency ultrasonography was also performed. The psoriasis area and severity index (PASI) score and efficacy indicators were compared between the two groups. The results showed that the detection rate of nail malnutrition and psoriasis infiltration in psoriasis by high-frequency ultrasound was significantly higher than that by arthroscopy, and the difference was significant (P < 0.05). The total PASI score of the two groups after treatment was significantly lower than that before treatment, and the total PASI score of the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). The total effective rate of the observation group (87.5%) was significantly higher than that of the control group (67.5%), and the difference was statistically significant (P < 0.05). It was found that high-frequency ultrasound can effectively display the condition and prognosis of patients with psoriasis. Ephedra-forsythia-red bean decoction was an effective traditional Chinese medicine formula for the treatment of psoriasis vulgaris.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of general data of patients between two groups. (a) The number of males and females; (b) the maximum age, minimum age, and mean age; (c) the maximum disease course, minimum disease course, and mean disease course; (d) the height and weight.
Figure 2
Figure 2
Patients' skin lesion area in observation group and control group before and after treatment. (a) Head, face, and neck; (b) upper limb; (c) trunk; (d) lower limb.
Figure 3
Figure 3
Severity of skin lesions in observation group and control group before and after treatment. (a) Head, face, and neck; (b) upper limb; (c) trunk; (d) lower limb. ∗ indicated that the difference between the observation group and the control group was statistically significant (P < 0.05).
Figure 4
Figure 4
Comparison of PASI scores between the two groups before and after treatment. (a) Head, face, and neck; (b) upper limb; (c) trunk; (d) lower limb. ∗ showed difference between before and after treatment was statistically significant (P < 0.05); # indicated that the difference between the observation group and the control group was statistically significant (P < 0.05).
Figure 5
Figure 5
Comparison of total PASI score between the two groups before and after treatment. ∗ indicated that the difference between before and after treatment was statistically significant (P < 0.05); # indicated that the difference between the observation group and the control group was statistically significant (P < 0.05).
Figure 6
Figure 6
Comparison of efficacy indicators between the two groups after treatment. (a) The number of cured, markedly effective, effective, and ineffective cases; (b) the total efficiency. ∗Significant difference between the observation group and the control group (P < 0.05).
Figure 7
Figure 7
Detection results of psoriasis nail lesions by high-frequency ultrasound and arthroscopy. ∗Difference between high-frequency ultrasound and arthroscopy was statistically significant (P < 0.05).
Figure 8
Figure 8
Normal skin and ultrasound images.
Figure 9
Figure 9
Psoriasis skin and ultrasound images.
See this image and copyright information in PMC

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