Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 30:2022:4632823.
doi: 10.1155/2022/4632823. eCollection 2022.

Left Atrial Appendage Depth and Tachycardia Bradycardia Syndrome as Important Predictors of Left Atrial Appendage Thrombus in Patients with Nonvalvular Atrial Fibrillation

Yinge He  1 , Panpan Chen  1 , Ziqiang Zhu  1 , Junhua Sun  1 , Yujie Zhao  1
Affiliations

Left Atrial Appendage Depth and Tachycardia Bradycardia Syndrome as Important Predictors of Left Atrial Appendage Thrombus in Patients with Nonvalvular Atrial Fibrillation

Yinge He et al. Comput Math Methods Med. .

Retraction in

Abstract

Background: Atrial fibrillation (AF) is the most common heart rhythm disorder that has been shown to be associated with a significant increase in stroke and systemic embolism risk. The left atrial appendage (LAA) is a finger-like extension originating from the left atrium; the formation of thrombus in LAA is the main reason of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). This study is aimed at finding out the risk of left atrial appendage thrombus (LAAT) in patients with nonvalvular atrial fibrillation (NVAF).

Method: We retrospectively examined the clinic and left atrial computer tomography angiography (CTA) features of patients assessed in Zhengzhou No. 7 People's Hospital between January 2020 and January 2021 derivation. Student's t-test, chi-square test, receiver operating characteristics (ROC) curves, and logistic regression analysis were used to identify predictors of LAAT.

Result: Of 480 patients included in the analysis, LAAT was found in approximately 9.2% of all patients. Univariate demographic predictors of LAAT included left atrium top and bottom diameter (LTD), left atrial appendage depth (LAAD), CHA2DS2-VASc, tachycardia bradycardia syndrome (TBS), and nonparoxysmal atrial fibrillation (PAF). In a multiple logistic regression analysis, the independent predictors of thrombus were LAAD > 23.45 mm (odds ratio: 4.216, 95% CI: 1.869-9.510, P = 0.001), TBS (odds ratio: 4.076, 95% CI: 1.655-10.038, P = 0.002), and non-PAF (odds ratio: 2.896, 95% CI: 1.183-7.094, P = 0.02).

Conclusion: In NVAF patients with LAAT, evidence suggested that larger LAAD, non-PAF, and TBS present a high risk of LAAT. This is the first report demonstrating that the LAAD and TBS are associated with LAAT in patients with NVAF.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
ROC curve for LAAD, LTD, and CHA2DS2-VASc score. LAAD: left atrial appendage depth; LTD: left atrium top and bottom diameter.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Benjamin E. J., Blaha M. J., Chiuve S. E., et al. Heart Disease and Stroke Statistics-2017 Update: a report from the American Heart Association. 2017;135(10) doi: 10.1161/CIR.0000000000000491. - DOI - PMC - PubMed
    1. Wang A., Green J. B., Halperin J. L., Piccini J. P., Sr. Atrial fibrillation and diabetes mellitus. Journal of the American College of Cardiology . 2019;74(8):1107–1115. doi: 10.1016/j.jacc.2019.07.020. - DOI - PubMed
    1. Choudhury A., Lip G. Y. Atrial fibrillation and the hypercoagulable state: from basic science to clinical practice. Pathophysiology of Haemostasis and Thrombosis . 2003;33(5-6):282–289. doi: 10.1159/000083815. - DOI - PubMed
    1. Zateyshchikov D. A., Brovkin A. N., Chistiakov D. A., Nosikov V. V. Advanced age, low left atrial appendage velocity, and factor V promoter sequence variation as predictors of left atrial thrombosis in patients with nonvalvular atrial fibrillation. Journal of Thrombosis and Thrombolysis . 2010;30(2):192–199. doi: 10.1007/s11239-010-0440-1. - DOI - PubMed
    1. Holmes D. R., Reddy V. Y., Turi Z. G., et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet . 2009;374(9689):534–542. doi: 10.1016/S0140-6736(09)61343-X. - DOI - PubMed

Publication types