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Case Reports
. 2022 Apr 4;13(4):20542704221086166.
doi: 10.1177/20542704221086166. eCollection 2022 Apr.

ASIA syndrome: Adverse reaction or autoimmunity?

Diogo André  1 , Fabiana Gouveia  1 , Rafael Nascimento  1 , Helena Luís  1 , Mónica Caldeira  1 , Caldeira Ferreira  2 , António José Chaves  1
Affiliations
Case Reports

ASIA syndrome: Adverse reaction or autoimmunity?

Diogo André et al. JRSM Open. .

Retraction in

Abstract

Introduction: Adjuvant-Induced Autoimmune / Auto-inflammatory Syndrome (ASIA) is an immune-mediated condition by the exposure of material previously considered inert, such as silicone, aluminum salts, mineral oils, hyaluronic acid and metallic implants. In addition to a genetic component, there is a risk of development of an undifferentiated connective tissue disease, which varies clinically and laboratorially depending on the adjuvant material used.

Patients and methods: This paper addresses two cases reported, in caucasian subjects, born and residents in Madeira Island, Portugal. In this article are described two different histological patterns occurring in ASIA patients, due to mammoplasty with silicone.

Conclusion: Although ASIA does not meet the diagnostic requirements for connective tissue disease, there is a close relationship with the development of autoimmune conditions. These cases aim to alert the medical community to the existence of this entity, encourage the notification of situations arising from exposure to adjuvants and investigate the presence of a genetic predisposition and a suggestive histological pattern in excisional biopsies of satellite adenomegalies.

Keywords: ASIA Syndrome; Adjuvants; Shoenfeld; Silicone.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Chest radiograph of 42-year-old female patient with bilateral breast implants for nine years, oriented to internal medicine due to asthenia, non-selective anorexia, fever and weight loss.
Figure 2.
Figure 2.
PETscan suggesting metastic lymphadenopathies of a 53-year-old female patient with mammoplasty following mastectomy due to breast cancer, oriented to internal medicine due to weight loss, asthenia and cervical nodule.
See this image and copyright information in PMC

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