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Case Reports
. 2022 Apr 6;14(4):e23879.
doi: 10.7759/cureus.23879. eCollection 2022 Apr.

Apixaban-Induced Hepatotoxicity

Umair Ansari  1 , Zahra Asghar  1 , Meghan Oswald  2 , Hong Ng  1
Affiliations
Case Reports

Apixaban-Induced Hepatotoxicity

Umair Ansari et al. Cureus. .

Abstract

Apixaban is widely used to prevent and manage thromboembolic disease. Due to it being fairly new in the market, we are still understanding its complete risk profile. We present a case of a 61-year-old female with no prior history of liver disease, who developed severe transaminitis shortly after the initiation of apixaban and started trending down after its discontinuation.

Keywords: adult gastroenterology; apixaban; cardiology research; general internal medicine; general pharmacology; hepatotoxicity; lft - liver function tests.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Liver enzymes
AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase.
See this image and copyright information in PMC

References

    1. Rivaroxaban and other novel oral anticoagulants: pharmacokinetics in healthy subjects, specific patient populations and relevance of coagulation monitoring. Mueck W, Schwers S, Stampfuss J. Thrombosis J. 2013;11:10. - PMC - PubMed
    1. Agrawal A, Kerndt CC, Manna B. Apixaban. Treasure Island (FL): StatPearls Publishing; 2022. - PubMed
    1. Apixaban versus warfarin in patients with atrial fibrillation. Granger CB, Alexander JH, McMurray JJV. N Engl J Med. 2011;365:981–992. - PubMed
    1. An observational study of the factor Xa inhibitors rivaroxaban and apixaban as reported to eight poison centers. Spiller HA, Mowry JB, Aleguas A Jr, et al. Ann Emerg Med. 2016;67:189–195. - PubMed
    1. Apixaban-induced liver injury. Clarke SA, Alsaad AA, Mack A, Phillips MB. BMJ Case Rep. 2016;2016 - PMC - PubMed

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