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Review
. 2022;4(1):90.
doi: 10.1007/s42399-022-01167-4. Epub 2022 Apr 4.

Post-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and management

Bala Munipalli  1 , Lynsey Seim  2 , Nancy L Dawson  2 , Dacre Knight  1 , Abd Moain Abu Dabrh  1   3
Affiliations
Review

Post-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and management

Bala Munipalli et al. SN Compr Clin Med. 2022.

Abstract

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 220 countries and territories have been affected by this virus, and the infection rate has continued to rise. As patients recover from the virus, many are experiencing lingering symptoms. Understanding the impact of demographics and comorbidities on symptom prevalence, manifestations, and severity is not only relevant during acute infection, it is critical to the clinical management of patients with post-acute sequelae of COVID-19, also known as PASC. Herein, we provide a comprehensive review on the most recent research related to PASC. Specifically, we focus on the description of the disorder itself, compared to acute COVID-19, and which types of patients are most affected by long-term sequelae. Further, we share recommendations for management of the most common complications of PASC.

Keywords: Complications; Management; Post-acute sequelae of COVID-19.

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Conflict of interest statement

Conflicts of Interest/Competing Interests (Include Appropriate Disclosures)The authors report no conflict of interest.

Figures

Fig. 1
Fig. 1
Mapping analysis
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