Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 3;1(4):331-337.
doi: 10.21873/cdp.10044. eCollection 2021 Sep-Oct.

Correlation Between the Transient Elevation of Peripheral Eosinophil Count During Radiotherapy and Acute Diarrhea

Takako Kobayashi  1 , Fumiaki Isohashi  1 , Daisuke Eino  1 , Kazunori Tanaka  1 , Kenjiro Sawada  2 , Yutaka Ueda  2 , Eiji Kobayashi  2 , Takuji Tomimatsu  2 , Tadashi Kimura  2 , Kazuhiko Ogawa  1
Affiliations

Correlation Between the Transient Elevation of Peripheral Eosinophil Count During Radiotherapy and Acute Diarrhea

Takako Kobayashi et al. Cancer Diagn Progn. .

Abstract

Background/aim: This study aimed to evaluate the association between the change in peripheral eosinophil count during postoperative pelvic radiotherapy and gastrointestinal (GI) toxicities in patients with cervical cancer.

Patients and methods: The medical records of 163 patients with cervical cancer who underwent postoperative concurrent chemoradiotherapy between 2000 and 2016 were analyzed.

Results: Among the peripheral blood cell counts, transient elevation of the eosinophil count was observed during radiotherapy. Of the 163 patients, 117 developed grade ≥2 diarrhea during radiotherapy, and 25 patients developed grade ≥2 late GI toxicities. In multivariate analysis, the maximum eosinophil count and age emerged as independent predictors of grade ≥2 acute diarrhea during radiotherapy, while bowel bag V 40 Gy and age were predictive of grade ≥2 late GI toxicities.

Conclusion: Early detection of transient elevation of eosinophil may facilitate early treatment of acute diarrhea during radiotherapy.

Keywords: Acute diarrhea; cervical neoplasm; eosinophil; late; postoperative; toxicity.

PubMed Disclaimer

Conflict of interest statement

All Authors declare no conflicts of interest with regards to preparation and content of this article.

Figures

Figure 1
Figure 1. Time course of blood cell counts during radiotherapy in patients with cervical cancer treated with postoperative concurrent chemoradiotherapy. WBC: white blood cells. *Significantly different at p<0.001.
Figure 2
Figure 2. Kaplan–Meier estimates of progression-free-survival according to maximum eosinophil count.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Peters WA 3rd, Liu PY, Barrett RJ 2nd, Stock RJ, Monk BJ, Berek JS, Souhami L, Grigsby P, Gordon W Jr, Alberts DS. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000;18(8):1606–1613. doi: 10.1200/JCO.2000.18.8.1606. - DOI - PubMed
    1. Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, Kawano Y, Ota Y, Inokuchi H, Shinjo H, Saito T, Fujiwara S, Sawasaki T, Ando K, Horie K, Okamoto H, Murakami N, Hasumi Y, Kasamatsu T, Toita T. A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors. Int J Clin Oncol. 2019;24(5):575–582. doi: 10.1007/s10147-018-01380-z. - DOI - PMC - PubMed
    1. Isohashi F, Mabuchi S, Akino Y, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yoshino K, Sawada K, Ueda Y, Kobayashi E, Sumida I, Mizuno H, Okubo H, Kimura T, Ogawa K. Dose-volume analysis of predictors for chronic gastrointestinal complications in patients with cervical cancer treated with postoperative concurrent chemotherapy and whole-pelvic radiation therapy. J Radiat Res. 2016;57(6):668–676. doi: 10.1093/jrr/rrw037. - DOI - PMC - PubMed
    1. Isohashi F, Yoshioka Y, Mabuchi S, Konishi K, Koizumi M, Takahashi Y, Ogata T, Maruoka S, Kimura T, Ogawa K. Dose-volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer. Int J Radiat Oncol Biol Phys. 2013;85(3):728–734. doi: 10.1016/j.ijrobp.2012.05.021. - DOI - PubMed
    1. Isohashi F, Mabuchi S, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yamashita M, Unno H, Kinose Y, Kozasa K, Sumida I, Otani Y, Kimura T, Ogawa K. Intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent nedaplatin-based chemotherapy after radical hysterectomy for uterine cervical cancer: comparison of outcomes, complications, and dose-volume histogram parameters. Radiat Oncol. 2015;10:180. doi: 10.1186/s13014-015-0486-5. - DOI - PMC - PubMed

LinkOut - more resources