Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 3;1(4):371-377.
doi: 10.21873/cdp.10049. eCollection 2021 Sep-Oct.

High Expression of PEA15 Is Associated With Patient Survival in Malignant Pleural Mesothelioma

Shajedul Islam  1   2 , Takao Kitagawa  1 , Yasuhiro Kuramitsu  1
Affiliations

High Expression of PEA15 Is Associated With Patient Survival in Malignant Pleural Mesothelioma

Shajedul Islam et al. Cancer Diagn Progn. .

Abstract

Background/aim: Malignant pleural mesothelioma (MPM) is a rare but very aggressive tumor that is primarily pleural in origin. The 5-year overall survival rate of patients with MPM has not improved despite therapeutic advances. Therefore, biomarker discovery to identify premalignant or early malignant tumors of the mesothelium are crucial. PEA15 is a cytoplasmic protein that is involved in various human malignancies, including MPM. However, the clinicopathological involvement of PEA15 in MPM has not yet been documented.

Materials and methods: The Oncomine database and GEPIA2 platform were used to analyze PEA15 mRNA expression and patient survival in patients with MPM.

Results: PEA15 was found to be significantly up-regulated in MPM, and this up-regulation inversely correlated with prolonged patient survival. Further, PEA15 expression was found to be increased in other cancer tissues without affecting overall survival.

Conclusion: PEA15 may represent a new potential prognostic biomarker in MPM patients.

Keywords: Mesothelioma; PEA15; bioinformatics; proteomics.

PubMed Disclaimer

Conflict of interest statement

The Authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1. mRNA expression and Kapan-Meier survival analysis of PEA15 in mesothelioma patients. (a) The mRNA expression level analysis of PEA15 in MPM tissues. The boxplots were downloaded from the Oncomine database. The light blue box represents normal lung (n=4) and pleural tissues (n=5), wherein the dark blue box represents MPM tissues (n=40). p=0.05 was regarded as statistically significant. (b) The overall survival analysis of PEA15 was performed by using the GEPIA2 platform. The overall survival curve of mesothelioma patients compared between a high PEA15 expression group (red line) and a low PEA15 expression group (blue line). p=0.01 was regarded as statistically significant.
Figure 2
Figure 2. The mRNA expression level analysis of PEA15 in different cancer tissues. The boxplots were downloaded from the GEPIA2. The red boxes represent the expression levels in cancerous tissues. In contrast, the blue boxes represent the expression levels in normal tissues. p=0.05 was regarded as statistically significant. ACC: Adrenocortical carcinoma; BLCA: bladder urothelial carcinoma; BRCA: breast invasive carcinoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: cholangiocarcinoma; COAD: colon adenocarcinoma; DLBC: lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: esophageal carcinoma; GBM: glioblastoma multiforme; HNSC: head and neck squamous cell carcinoma; KICH: kidney chromophobe; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LAML: acute myeloid leukemia; LGG: brain lower grade glioma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; OV: ovarian serous cystadenocarcinoma; PAAD: pancreatic ductal adenocarcinoma; PCPG: pheochromocytoma and paraganglioma; PRAD: prostate adenocarcinoma; READ: rectum adenocarcinoma; SARC: sarcoma; SKCM: skin cutaneous melanoma; STAD: stomach adenocarcinoma; TGCT: testicular germ cell tumors; THCA: thyroid carcinoma; THYM: thymoma; UCEC: uterine corpus endometrial carcinoma; UCS: uterine carcinosarcoma; UVM: uveal melanoma.
Figure 3
Figure 3. Kaplan-Meier survival plots of different cancerous tissues with higher PEA15 levels. The Kaplan-Meier plots were generated using the GEPIA2 platform. Overall survival curve of different cancerous tissues compared between a high PEA15 expression group (red line) and a low PEA15 expression group (blue line). p=0.01 was regarded as statistically significant.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Pass HI, Alimi M, Carbone M, Yang H, Goparaju CM. Mesothelioma biomarkers: A review highlighting contributions from the Early Detection Research Network. Cancer Epidemiol Biomarkers Prev. 2020;29(12):2524–2540. doi: 10.1158/1055-9965.EPI-20-0083. - DOI - PubMed
    1. Lippolis R, De angelis M. Proteomics and human diseases. Journal of Proteomics & Bioinformatics. 2017;09(03):63–74. doi: 10.4172/jpb.1000391. - DOI
    1. Kuramitsu Y, Miyamoto H, Tanaka T, Zhang X, Fujimoto M, Ueda K, Tanaka T, Hamano K, Nakamura K. Proteomic differential display analysis identified upregulated astrocytic phosphoprotein PEA-15 in human malignant pleural mesothelioma cell lines. Proteomics. 2009;9(22):5078–5089. doi: 10.1002/pmic.200800284. - DOI - PubMed
    1. Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47(W1):W556–W560. doi: 10.1093/nar/gkz430. - DOI - PMC - PubMed
    1. Mohammed HN, Pickard MR, Mourtada-Maarabouni M. The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cell Signal. 2016;28(9):1389–1400. doi: 10.1016/j.cellsig.2016.06.011. - DOI - PubMed

LinkOut - more resources