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. 2022 Jan-Dec:29:10732748221091333.
doi: 10.1177/10732748221091333.

Predictive Values of the Selected Inflammatory Indexes in Colon Cancer

Li Huang  1 , Zuojian Hu  1 , Ruixian Luo  2 , Hailan Li  2 , Ziji Yang  2 , Xue Qin  1 , Zhuning Mo  2
Affiliations

Predictive Values of the Selected Inflammatory Indexes in Colon Cancer

Li Huang et al. Cancer Control. 2022 Jan-Dec.

Abstract

Purpose: Ample evidence has revealed that the lymphocyte-to-monocyte ratio (LMR), albumin-to-globulin ratio (AGR), and mean platelet volume (MPV) are cancer-related inflammatory markers. The present study aimed to combine these indicators to better assess the progression of colon cancer.

Methods: This retrospective study enrolled 251 patients with colon cancer, 171 patients with benign colon diseases, and 187 healthy control subjects. The receiver operating characteristic curve and area under the curve (AUC) were used to determine the diagnostic values of the selected inflammatory index.

Results: The levels of LMR, AGR, and MPV were decreased in the colon cancer group compared with the healthy control and benign colon disease groups. The LMR, AGR, and MPV were all correlated with tumor size. Moreover, LMR and AGR was associated with lymph node metastasis and clinical stage, AGR was related to distant metastasis. Both the LMR (P = .030) and AGR (P = .005) were negatively correlated with the concentration of carcinoembryonic antigen (CEA). The AUC value of MPV combined with CEA had a good diagnostic ability for distinguishing colon cancer cases (AUC = .950) and patients with benign colon diseases (AUC = .886) from controls. Meanwhile, the combination of LMR or AGR with CEA could enhance larger AUC (.746 for LMR + CEA, .737 for AGR + CEA) than CEA, LMR, or AGR alone in detecting colon cancer from benign colon diseases.

Conclusions: CEA combined with the LMR, AGR, or MPV may be used as better blood-based biomarkers in the progression of colon cancer patients.

Keywords: albumin-to-globulin ratio; colon cancer; diagnosis; lymphocyte-to-monocyte ratio; mean platelet volume.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison of LMR and AGR among three groups. (A): LMR (B): AGR. (C): MPV. Note. LMR: lymphocyte-to-monocyte ratio, AGR: albumin to globulin ratio, MPV: mean platelet volume.
Figure 2.
Figure 2.
Correlation analysis of LMR, AGR, MPV, and CEA in patients with colon cancer. (A). LMR and CEA with colon cancer, (B). AGR and CEA with colon cancer, (C). MPV and CEA with colon cancer. Note. LMR: lymphocyte-to-monocyte ratio, AGR: albumin to globulin ratio, MPV: mean platelet volume, CEA: carcinoembryonic antigen.
Figure 3.
Figure 3.
The diagonstic value of LMR, AGR, and MPV used alone or in combination with CEA in the progression of colon cancer. (A). colon cancer vs healthy controls, (B). colon cancer vs benign colon diseases, (C). benign colon diseases vs healthy controls. Note. LMR: lymphocyte-to-monocyte ratio, AGR: albumin to globulin ratio, MPV: mean platelet volume, CEA: carcinoembryonic antigen
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