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. 2022 Mar;23(2):145-153.
doi: 10.5152/TurkThoracJ.2022.21076.

Charlson Comorbidity Index in Predicting Poor Clinical Outcomes and Mortality in Patients with COVID-19

Serap Argun Barış  1 , Haşim Boyacı  1 , Sıla Akhan  2 , Birsen Mutlu  2 , Müge Deniz  2 , İlknur Başyiğit  1
Affiliations

Charlson Comorbidity Index in Predicting Poor Clinical Outcomes and Mortality in Patients with COVID-19

Serap Argun Barış et al. Turk Thorac J. 2022 Mar.

Abstract

Objective: As known, older age and comorbidities are associated with poor clinical outcomes in patients with coronavirus disease 19. The aim of this study was to investigate the effect of the Charlson Comorbidity Index in predicting poor clinical outcomes in coronavirus disease 19 patients.

Material and methods: Demographic characteristics and poor clinical outcomes (presence of pneumonia, respiratory failure, intensive care unit admission, and mortality) of the patients were evaluated retrospectively. Classical and modified Charlson Comorbidity Index was calculated and adjusted according to age.

Results: In this study, 106 women and 107 men were included. The comorbidity rate was 50.7% and the most common comorbidities were hypertension (21.6%) and diabetes mellitus (15%). The rates of respiratory failure, intensive care unit admission, and mortality were 15%, 2.3%, and 2.8%, respectively. Older age was a high risk for poor outcomes. Pneumonia (odds ratio: 6.6; 95% CI: 3.4-12.7), respiratory failure (odds ratio: 5.2; 95% CI: 2.03-13.2), and intensive care unit admission (odds ratio: 1.1; 95% CI: 1.01-1.1) were significantly higher in patients with comorbid diseases than patients without any comorbidity (P < .05). Both median-modified and classical Charlson Comorbidity Index and their age-adjusted scores were significantly higher in patients with poor outcomes.

Conclusions: It is suggested that evaluation of the Charlson Comorbidity Index might contribute to the management of the patients with coronavirus disease 19 by predicting risk group for poor clinical outcomes and mortality.

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Figures

Figure 1.
Figure 1.
Flowchart of the study.
Figure 2.
Figure 2.
Most common comorbidities of the patients with COVID-19. COVID-19, coronavirus disease 19.
Figure 3.
Figure 3.
Clinical outcomes and mortality rates according to the classification of age-adjusted, modified CCI scores. CCI, Charlson Comorbidity Index.
Figure 4.
Figure 4.
Clinical outcomes and mortality rates according to the classification of age-adjusted classical CCI scores. CCI, Charlson Comorbidity Index.
See this image and copyright information in PMC

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