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Review
. 2022 Apr 2;14(7):1496.
doi: 10.3390/nu14071496.

A Molecular Approach to Understanding the Role of Diet in Cancer-Related Fatigue: Challenges and Future Opportunities

Sylvia L Crowder  1 , Mary C Playdon  2   3 , Lisa M Gudenkauf  1 , Jennifer Ose  4   5 , Biljana Gigic  6 , Leigh Greathouse  7 , Anita R Peoples  4   5 , Alix G Sleight  8   9 , Heather S L Jim  1 , Jane C Figueiredo  9   10
Affiliations
Review

A Molecular Approach to Understanding the Role of Diet in Cancer-Related Fatigue: Challenges and Future Opportunities

Sylvia L Crowder et al. Nutrients. .

Abstract

Cancer-related fatigue (CRF) is considered one of the most frequent and distressing symptoms for cancer survivors. Despite its high prevalence, factors that predispose, precipitate, and perpetuate CRF are poorly understood. Emerging research focuses on cancer and treatment-related nutritional complications, changes in body composition, and nutritional deficiencies that can compound CRF. Nutritional metabolomics, the novel study of diet-related metabolites in cells, tissues, and biofluids, offers a promising tool to further address these research gaps. In this position paper, we examine CRF risk factors, summarize metabolomics studies of CRF, outline dietary recommendations for the prevention and management of CRF in cancer survivorship, and identify knowledge gaps and challenges in applying nutritional metabolomics to understand dietary contributions to CRF over the cancer survivorship trajectory.

Keywords: cancer survivors; diet-related disease; dietary intervention; metabolomics; nutrition.

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Conflict of interest statement

Heather S. L. Jim is a consultant for RedHill BioPharma, Janssen Scientific Affairs, and Merck.

Figures

Figure 1
Figure 1
Nutritional Metabolomics in Cancer Survivorship.
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