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Review
. 2022 Mar 30;12(7):1145.
doi: 10.3390/nano12071145.

Polydopamine-Coated Magnetic Iron Oxide Nanoparticles: From Design to Applications

Giulia Siciliano  1 , Anna Grazia Monteduro  1 , Antonio Turco  2 , Elisabetta Primiceri  2 , Silvia Rizzato  1 , Nicoletta Depalo  3 , Maria Lucia Curri  3   4 , Giuseppe Maruccio  1
Affiliations
Review

Polydopamine-Coated Magnetic Iron Oxide Nanoparticles: From Design to Applications

Giulia Siciliano et al. Nanomaterials (Basel). .

Abstract

Magnetic iron oxide nanoparticles have been extensively investigated due to their applications in various fields such as biomedicine, sensing, and environmental remediation. However, they need to be coated with a suitable material in order to make them biocompatible and to add new functionalities on their surface. This review is intended to give a comprehensive overview of recent advantages and applications of iron oxide nanoparticles coated by polydopamine film. The synthesis method of magnetic nanoparticles, their functionalization with bioinspired materials and (in particular) with polydopamine are discussed. Finally, some interesting applications of polydopamine-coated magnetic iron oxide nanoparticles will be pointed out.

Keywords: bioinspired nanomaterials; iron oxide nanoparticles; magnetic nanoparticles; polydopamine; surface functionalization.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distinct structures of magnetic bionanocomposites: (A) core-shell Fe3O4 polydopamine nanoparticles (Fe3O4@PDA NPs) (reproduced with permission from ref. [45]. Copyright 2017 Elsevier); (B) Polydopamine@upconversion nanoparticle@mesoporous silica yolk-shell nanoparticles (PDA@UCNP@mSiO2 NPs) (reproduced with permission from ref. [46]. Copyright 2020 Elsevier); (C) Mosaic Fe3O4 polydopamine nanoparticles; (D) Au speckled SPION@SiO2 NPs (reproduced with permission from ref. [33]. Copyright 2020 John Wiley and Sons); (E) Polyethylene glycol (PEG) stabilized MnFe2O4@MnO Janus nanoparticles (reproduced with permission from ref. [48]. Copyright 2003 Royal Society of Chemistry); (F) Polymer-stabilized ferromagnetic γ-Fe2O3 dumbell nanoparticles (reproduced with permission from ref. [49]. Copyright 2013 ACS Publications).
Figure 2
Figure 2
Number of publications with keywords: nanoparticles in combination with ■ sensing, ● biomedicine or nanomedicine or drug delivery, and ▲ bioremediation or remediation in the last years.
Figure 3
Figure 3
The structure of Fe3O4/PDA and its interaction with metal ions. Influence on adsorption of (a) pH and ionic strength; (b) concentration; (c) Langmuir model for Cd(II) adsorption, where Qe (mg/g) is the equilibrium adsorption capacity and Ce is the Cd(II) concentration at the equilibrium conditions. Reproduced with permission from ref. [74]. Copyright 2019 Elsevier.
Figure 4
Figure 4
(A) Relative viabilities of A549 cells treated with Fe3O4, PDA, and Fe3O4@PDA at a concentration of 50 μg mL−1 without or with NIR laser irradiation; (B) Photograph of tumors after excision from PBS, Fe3O4, PDA, and Fe3O4@PDA under NIR irradiation (reproduced with permission from ref. [88]. Copyright 2015 ACS Publications); (C) T1-Weighted MR imaging of xenograft 4T1 tumors in mice before and at different time points post intravenous injection of ultrasmall iron oxide nanoparticles (USIONPs); (D) MR signal/noise (S/N) ratios of tumors at different time points (reproduced with permission from ref. [28]. Copyright 2013 Royal Society of Chemistry); (E) Simultaneous detection of multiple mRNAs in living cells (reproduced with permission from ref. [39]. Copyright 2014 ACS Publications).
Figure 5
Figure 5
(A) Capture and detection of the target Pb(II) in sample solution; (B) Differential pulse voltammograms of the developed nanocomposites (reproduced with permission from ref. [101]); (C) Schematic illustration of the fabrication process of Fe3O4NPs MMIPs; (D) Cyclic voltammetry from Fe3O4NPs MMIPs-modified glassy carbon electrode (GCE) dose dependent (reproduced with permission from ref. [102]. Copyright 2017 Elsevier).
See this image and copyright information in PMC

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