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Review
. 2022 Mar 30;12(7):1149.
doi: 10.3390/nano12071149.

Graphene Oxide Thin Films with Drug Delivery Function

Alexandra M L Oliveira  1   2   3 , Mónica Machado  1   2   3 , Gabriela A Silva  2   3 , Diogo B Bitoque  2   3 , Joana Tavares Ferreira  4   5 , Luís Abegão Pinto  4   5 , Quirina Ferreira  1
Affiliations
Review

Graphene Oxide Thin Films with Drug Delivery Function

Alexandra M L Oliveira et al. Nanomaterials (Basel). .

Abstract

Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

Keywords: drug delivery; graphene oxide; layer-by-layer; polyelectrolyte multilayer films.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Graphical representation of the molecular structures of different graphene-based materials. Republished from Ref. [18].
Figure 2
Figure 2
Schematics of the different LbL assembling methods. (A)—Langmuir–Blodgett assembly; (B)—microfluidics; (C)—drop coating; (D)—perfusion, (E)—dip coating; (F)—spray coating; (G)—spin coating. Figure created with BioRender.com.
Figure 3
Figure 3
Schematic representation of rGO hollow capsules assembly. Republished with permission from Ref. [3]. Copyright 2022 American Chemical Society.
Figure 4
Figure 4
Schematic representation of the GO-ThS system used for AD treatment. Upon NIR irradiation, the GO-ThS system can dissolve the Aβ amyloid deposits. Republished with permission from Ref. [15]. Copyright 2022 John Wiley and Sons.
Figure 5
Figure 5
Fluorescence images of Aβ incubated with GO-ThS in Tris buffer (A) and mice CSF (B) (200x magnification) demonstrate that upon NIR irradiation GO-ThS can effectively dissociate Aβ amyloid deposits. Republished with permission from Ref. [15]. Copyright 2022 John Wiley and Sons.
See this image and copyright information in PMC

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