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. 2022 Mar 29;11(7):1906.
doi: 10.3390/jcm11071906.

Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors

Shadi Katou  1 , Franziska Schmid  1 , Carolina Silveira  1 , Lina Schäfer  1 , Tizian Naim  1 , Felix Becker  1 , Sonia Radunz  1 , Mazen A Juratli  1 , Leon Louis Seifert  2 , Hauke Heinzow  2   3 , Benjamin Struecker  1 , Andreas Pascher  1 , M Haluk Morgul  1
Affiliations

Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors

Shadi Katou et al. J Clin Med. .

Abstract

Surgery has become well established for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs and for colorectal liver metastases (CRLMs) between 2012 and 2017 at our institution. Prognostic factors of overall and recurrence-free survival were analyzed, and a comparison of survival between two groups was performed. Seventy-three patients (30 NCRNNELM and 43 CRLM) were included in this study. Although the mean age, extrahepatic metastases, and rate of reoperation were significantly different between the groups, recurrence-free survival was comparable. The 5-year overall survival rates were 38% for NCRNNELM and 55% for CRLM. In univariate analysis, a patient age of ≥60 years, endodermal origin of the primary tumor, and major complications were negative prognostic factors. Resection for NCRNNELM showed comparable results to resection for CRLM. Age, the embryological origin of the primary tumor, and the number of metastases might be the criteria for patient selection.

Keywords: colorectal liver metastases; liver metastases; liver resection; non-colorectal and non-neuroendocrine liver metastases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of patient inclusion.
Figure 2
Figure 2
Kaplan–Meier analysis of the overall and recurrence-free survival of patients with NCRNNE and CRLM.
Figure 3
Figure 3
Kaplan–Meier analysis of the age (above and below 60 years) and embryological origin of the primary tumor on overall survival of the patient with NCRNNE.
Figure 3
Figure 3
Kaplan–Meier analysis of the age (above and below 60 years) and embryological origin of the primary tumor on overall survival of the patient with NCRNNE.
See this image and copyright information in PMC

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