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Review
. 2022 Mar 28;27(7):2175.
doi: 10.3390/molecules27072175.

Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents

Bilin Xu  1 , Zhiliang Li  1 , Ting Zeng  2 , Jianfeng Zhan  1 , Shuzhen Wang  1 , Chi-Tang Ho  3 , Shiming Li  1   3
Affiliations
Review

Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents

Bilin Xu et al. Molecules. .

Abstract

Momordica charantia L., a member of the Curcubitaceae family, has traditionally been used as herbal medicine and as a vegetable. Functional ingredients of M. charantia play important roles in body health and human nutrition, which can be used directly or indirectly in treating or preventing hyperglycemia-related chronic diseases in humans. The hypoglycemic effects of M. charantia have been known for years. In this paper, the research progress of M. charantia phytobioactives and their hypoglycemic effects and related mechanisms, especially relating to diabetes mellitus, has been reviewed. Moreover, the clinical application of M. charantia in treating diabetes mellitus is also discussed, hoping to broaden the application of M. charantia as functional food.

Keywords: Momordica charantia; bioactives; diabetes mellitus; hypoglycemic activity; synergistic effect.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of main M. charantia active substance. (A–H) referred to charantin, karaviloside XI, momordenol, momordicoside Q, momordicoside S, momordicoside T, 9c,11t,13t-CLN, and momordicilin, respectively.
Figure 2
Figure 2
Chemical structure of main M. charantia cucurbitane-type triterpenoids.
Figure 3
Figure 3
Schematic illustrating of M. charantia active substance towards diabetes mellitus.
Figure 4
Figure 4
Chemical structure of the main M. charantia peptides derived from the hypoglycemic protein adMc1.
Figure 5
Figure 5
Schematic illustrating of M. charantia active substance towards obesity.
See this image and copyright information in PMC

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References

    1. Xiao J.B., Högger P. Dietary polyphenols and type 2 diabetes: Current insights and future perspectives. Curr. Med. Chem. 2015;22:23–38. doi: 10.2174/0929867321666140706130807. - DOI - PubMed
    1. Roglic G., Unwin N., Bennett H., Mathers C., Tuomilehto J., Nag S., Connolly V., King H. The burden of mortality attributable to diabetes: Realistic estimates for the year 2000. Diabetes Care. 2005;28:2130–2135. doi: 10.2337/diacare.28.9.2130. - DOI - PubMed
    1. ADA Classification and diagnosis of diabetes. Diabetes Care. 2015;40:S11–S24. - PubMed
    1. Zhao Y., Liu Y.J., Yi F.Z., Zhang J., Xu Z.H., Liu Y.H., Tao Y. Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in COVID-19 mild pneumonia patients. Int. Immunopharmacol. 2021;93:107406. doi: 10.1016/j.intimp.2021.107406. - DOI - PMC - PubMed
    1. Salamone D., Rivellese A.A., Vetrani C. The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: The possible role of dietary fibre. Acta Diabetol. 2021;58:1131–1138. doi: 10.1007/s00592-021-01727-5. - DOI - PMC - PubMed

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