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Review
. 2022 Mar 23;23(7):3478.
doi: 10.3390/ijms23073478.

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Matthew L Hedberg  1 , Corbett T Berry  1 , Ata S Moshiri  1 , Yan Xiang  1 , Christopher J Yeh  1 , Cem Attilasoy  1 , Brian C Capell  1 , John T Seykora  1
Affiliations
Review

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Matthew L Hedberg et al. Int J Mol Sci. .

Abstract

Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

Keywords: cancer biology; genetics of cancer; skin cancer; squamous cell carcinoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A representation of stages within the spectrum of human cutaneous neoplasia is shown with select histologic and molecular features.
See this image and copyright information in PMC

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