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. 2022 Mar 31;23(7):3876.
doi: 10.3390/ijms23073876.

Neuroprotection in Stroke-Focus on the Renin-Angiotensin System: A Systematic Review

Sebastian Andone  1   2 , Zoltan Bajko  2   3 , Anca Motataianu  2   3 , Smaranda Maier  2   3 , Laura Barcutean  2   3 , Rodica Balasa  1   2   3
Affiliations

Neuroprotection in Stroke-Focus on the Renin-Angiotensin System: A Systematic Review

Sebastian Andone et al. Int J Mol Sci. .

Abstract

Stroke is the primary cause of disability in the adult population. Hypertension represents the leading risk factor being present in almost half the patients. The renin-angiotensin system is involved in the physiopathology of stroke and has an essential impact on hypertension as a risk factor. This article targeted the role of the renin-angiotensin system in stroke neuroprotection by reviewing the current literature available. The mechanism of action of the renin-angiotensin system was observed through the effects on AT1, AT2, and Mas receptors. The neuroprotective properties ascertained by angiotensin in stroke seem to be independent of the blood pressure reduction mechanism, and include neuroregeneration, angiogenesis, and increased neuronal resistance to hypoxia. The future relationship of stroke and the renin-angiotensin system is full of possibilities, as new agonist molecules emerge as potential candidates to restrict the impairment caused by stroke.

Keywords: neuroprotection; renin-angiotensin; stroke.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram for the systematic review.
Figure 2
Figure 2
Angiotensin receptors and their roles.
See this image and copyright information in PMC

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