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. 2022 Apr 5;23(7):4027.
doi: 10.3390/ijms23074027.

Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature

Alessio Danilo Inchingolo  1 , Giuseppina Malcangi  1 , Angelo Michele Inchingolo  1 , Fabio Piras  1 , Vito Settanni  1 , Grazia Garofoli  1 , Giulia Palmieri  1 , Sabino Ceci  1 , Assunta Patano  1 , Nicole De Leonardis  1 , Chiara Di Pede  1 , Valentina Montenegro  1 , Daniela Azzollini  1 , Maria Grazia Garibaldi  1 , Zamira Kruti  1 , Antonella Tarullo  1 , Giovanni Coloccia  1 , Antonio Mancini  1 , Biagio Rapone  1 , Alexandra Semjonova  1 , Denisa Hazballa  1   2 , Maria Teresa D'Oria  1   3 , Megan Jones  1 , Luigi Macchia  4 , Ioana Roxana Bordea  5 , Antonio Scarano  6 , Felice Lorusso  6 , Gianluca Martino Tartaglia  7   8 , Cinzia Maspero  7   8 , Massimo Del Fabbro  7   9 , Ludovica Nucci  10 , Kenan Ferati  11 , Arberesha Bexheti Ferati  11 , Nicola Brienza  12 , Alberto Corriero  12 , Francesco Inchingolo  1 , Gianna Dipalma  1
Affiliations

Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature

Alessio Danilo Inchingolo et al. Int J Mol Sci. .

Abstract

Resveratrol is a polyphenol that has been shown to possess many applications in different fields of medicine. This systematic review has drawn attention to the axis between resveratrol and human microbiota, which plays a key role in maintaining an adequate immune response that can lead to different diseases when compromised. Resveratrol can also be an asset in new technologies, such as gene therapy. PubMed, Cochrane Library, Scopus, Web of Science, and Google Scholar were searched to find papers that matched our topic dating from 1 January 2017 up to 18 January 2022, with English-language restriction using the following Boolean keywords: ("resveratrol" AND "microbio*"). Eighteen studies were included as relevant papers matching the purpose of our investigation. Immune response, prevention of thrombotic complications, microbiota, gene therapy, and bone regeneration were retrieved as the main topics. The analyzed studies mostly involved resveratrol supplementation and its effects on human microbiota by trials in vitro, in vivo, and ex vivo. The beneficial activity of resveratrol is evident by analyzing the changes in the host's genetic expression and the gastrointestinal microbial community with its administration. The possibility of identifying individual microbial families may allow to tailor therapeutic plans with targeted polyphenolic diets when associated with microbial dysbiosis, such as inflammatory diseases of the gastrointestinal tract, degenerative diseases, tumors, obesity, diabetes, bone tissue regeneration, and metabolic syndrome.

Keywords: bone regeneration; dentistry; genic therapy; immune response; microbiome; microbiota; nutrition; resveratrol; resveratrol supplementation; thrombosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summary of the RSV metabolites and the main molecules indicated for their antioxidant and anti-inflammatory bioactivity.
Figure 2
Figure 2
Summary of the cytokines’ and mediators’ modulation correlated to the anti-inflammatory properties of RSV. The RSV is able to interact with the SIRT-1 pathway in order to inhibit the pro-inflammatory mediators’ cascade and the COX-1 and COX-2.
Figure 3
Figure 3
Summary of the pathway correlated to the bacteria infection protective properties of RSV. RSV pathways are able to produce a signals cascade involving Sirtuin 1 [SIRT-1], adenosine monophosphate (AMP)-activated protein Kinase [AMPK] (blue arrow), liver-kinase B1 [LKB1] (grey arrow), and peroxisome proliferator-activated receptor-γ coactivator [PGC-1α].
Figure 4
Figure 4
PRISMA flowchart diagram of the inclusion process [131].
See this image and copyright information in PMC

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