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Review
. 2022 Apr 6;23(7):4037.
doi: 10.3390/ijms23074037.

Sequence Requirements for miR-424-5p Regulating and Function in Cancers

Jiangying Xuan  1   2 , Yingxia Liu  1 , Xiaoping Zeng  1 , Hongmei Wang  1
Affiliations
Review

Sequence Requirements for miR-424-5p Regulating and Function in Cancers

Jiangying Xuan et al. Int J Mol Sci. .

Abstract

MiRNAs (microRNAs) are the most abundant family of small noncoding RNAs in mammalian cells. Increasing evidence shows that miRNAs are crucial regulators of individual development and cell homeostasis by controlling various biological processes. Therefore, miRNA dysfunction can lead to human diseases, especially in cancers with high morbidity and mortality worldwide. MiRNAs play different roles in these processes. In recent years, studies have found that miR-424-5p is closely related to the occurrence, development, prognosis and treatment of tumors. This review discusses how miR-424-5p plays a role in different kinds of cancers from different stages of tumors, including its roles in (i) promoting or inhibiting tumorigenesis, (ii) regulating tumor development in the tumor microenvironment and (iii) participating in cancer chemotherapy. This review provides a deep discussion of the latest findings on miR-424-5p and its importance in cancer, as well as a mechanistic analysis of the role of miR-424-5p in various tissues through target gene verification and pathway analysis.

Keywords: cancer; chemotherapy; miR-424-5p; tumor microenvironment; tumorigenesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The ways that miR-424-5p regulates cancer cell progression can be categorized into 4 mechanisms. (i) By controlling cell cycle. (ii) By promoting or inhibiting cancer cell proliferation, (iii) By regulating tumor cell apoptosis (iv) By acting on the processes that cancer cells have, such as the Warburg effect, metastasis, anoikis resistance, ferroptosis and angiogenesis. The targets of miR-424-5p can not only participate in one ways, but can have different roles in different mechanisms.
Figure 2
Figure 2
In HCC, miR-424-5p can be regulated by upstream pathways and regulate downstream pathways. (i) XIST can increase the expression of miR-424-5p, which inhibits ATG14, inhibiting HCC proliferation and migration. (ii) The decrease in DLX6-AS1 can target miR-424-5p to inhibit the expression of WEE1, which inhibits HCC proliferation and migration. (iii) PVT1 inhibits the expression of miR-424-5p by regulating the p53 signaling pathway to promote HCC proliferation. (iv) LncRNAs, including MYLK-AS1, CDKN2B-AS1, and CAS9, can affect the expression of miR-424-5p to regulate HCC progression.
Figure 3
Figure 3
MiR-424-5p can regulate ovarian cancer progression in 4 different ways. (i) MiR-424-5p can inhibit ACSL4 to prevent hypertrophy of primary ovarian cancer. (ii) MiR-424-5p decreases the expression of KIF23 to inhibit the proliferation and migration of ovarian cancer. (iii) MiR-424-5p targets CCNE1J directly to activate the E2F1-pRb signaling pathway, which results in an antitumor effect. (iv) MiR-424-5p increases the expression of MIEF2 to facilitate the Warburg effect.
See this image and copyright information in PMC

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