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. 2022 Jul;32(7):561-564.
doi: 10.1016/j.tcb.2022.03.003. Epub 2022 Apr 8.

Nucleolin: a binding partner of G-quadruplex structures

Tiago Santos  1 , Gilmar F Salgado  2 , Eurico J Cabrita  3 , Carla Cruz  4
Affiliations

Nucleolin: a binding partner of G-quadruplex structures

Tiago Santos et al. Trends Cell Biol. 2022 Jul.

Abstract

Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine-glycine-glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.

Keywords: G-quadruplex; interaction; ligands; nucleolin.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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