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. 2022 May:17:607-620.
doi: 10.2217/fmb-2021-0146. Epub 2022 Apr 12.

Antifungal activity of dexamethasone against fluconazole-resistant Candida albicans and its activity against biofilms

Lisandra J Silva  1   2 , Cecília R Silva  1   2 , Lívia Gav Sá  1   3   2 , Fatima Dd Barroso  1   2 , Thiago M Cândido  1   2 , Helaine A Queiroz  1   2 , Lara E Almeida Moreira  1   2 , Octavio V Baccallini  1   2 , Bruno C Cavalcanti  2 , Jacilene Silva  2 , Emmanuel S Marinho  2 , Manoel O Moraes  2 , João Ba Neto  1   3   2 , Hélio Vn Júnior  1   2
Affiliations

Antifungal activity of dexamethasone against fluconazole-resistant Candida albicans and its activity against biofilms

Lisandra J Silva et al. Future Microbiol. 2022 May.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Future Microbiol. 2022 Aug;17:983. doi: 10.2217/fmb-2021-0146c1. Epub 2022 Jun 13. Future Microbiol. 2022. PMID: 35695896 No abstract available.

Abstract

Objective: The present study investigated the antifungal action of dexamethasone disodium phosphate (Dex). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol; M27-A3, checkerboard test and biofilm were evaluated with two isolates of Candida albicans, hyphal production test, molecular docking analysis and flow cytometry analysis. Result: Dex and fluconazole (FLC) together had a synergistic effect. Mature biofilm was reduced when treated with Dex alone or in combination. Dex and FLC promoted a decrease in the production of hyphae and changes in the level of mitochondrial depolarization, increased generation of reactive oxygen species, loss of membrane integrity, increased phosphatidylserine externalization and molecular docking; there was interaction with ALS3 and SAP5 targets. Conclusion: Dex showed antifungal activity against FLC-resistant C. albicans strains.

Keywords: Candida spp.; biofilm; dexamethasone; repositioning.

Plain language summary

This study aimed to evaluate the antifungal action of dexamethasone against FLC-resistant C. albicans strains.

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