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. 2023 Jan;71(1):91-102.
doi: 10.1002/glia.24180. Epub 2022 Apr 12.

Endocannabinoid signaling in oligodendroglia

Eduardo Molina-Holgado  1 , Pedro F Esteban  1 , Ángel Arevalo-Martin  1 , Rafael Moreno-Luna  1 , Francisco Molina-Holgado  2 , Daniel Garcia-Ovejero  1
Affiliations

Endocannabinoid signaling in oligodendroglia

Eduardo Molina-Holgado et al. Glia. 2023 Jan.

Abstract

In the central nervous system, oligodendrocytes synthesize the myelin, a specialized membrane to wrap axons in a discontinuous way allowing a rapid saltatory nerve impulse conduction. Oligodendrocytes express a number of growth factors and neurotransmitters receptors that allow them to sense the environment and interact with neurons and other glial cells. Depending on the cell cycle stage, oligodendrocytes may respond to these signals by regulating their survival, proliferation, migration, and differentiation. Among these signals are the endocannabinoids, lipidic molecules synthesized from phospholipids in the plasma membrane in response to cell activation. Here, we discuss the evidence showing that oligodendrocytes express a full endocannabinoid signaling machinery involved in physiological oligodendrocyte functions that can be therapeutically exploited to promote remyelination in central nervous system pathologies.

Keywords: cannabinoid; differentiation; oligodendrocyte; signaling.

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References

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