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. 2023 Jul;30(4):582-600.
doi: 10.1080/13825585.2022.2065241. Epub 2022 Apr 12.

Subjective cognitive decline disrupts aspects of prospective memory in older adults with HIV disease

Jennifer L Thompson  1 , David P Sheppard  2 , Anastasia Matchanova  1 , Erin E Morgan  3 , Shayne Loft  4 , Steven Paul Woods  1   4
Affiliations

Subjective cognitive decline disrupts aspects of prospective memory in older adults with HIV disease

Jennifer L Thompson et al. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2023 Jul.

Abstract

Subjective cognitive decline (SCD) is a risk factor for dementia that may occur at higher rates in people with HIV (PWH). Prospective memory (PM) is an aspect of cognition that may help us better understand how SCD impacts daily life. Paricipants were 62 PWH aged ≥ 50 years and 33 seronegative individuals. SCD was operationalized as normatively elevated cognitive symptoms on standardized questionnaires, but with normatively unimpaired performance-based cognition and no current affective disorders. PM was measured with the Comprehensive Assessment of Prospective Memory (CAPM), the Cambridge Test of Prospective Memory (CAMPROMPT), and an experimental computerized time-based PM task. A logistic regression revealed that older PWH had a three-fold increased likelihood for SCD. Among the PWH, SCD was associated with more frequent PM symptoms and poorer accuracy on the time-based scale of the CAMPROMPT. These findings suggest that SCD disrupts PM in older PWH.

Keywords: Aging; everyday functioning; future thinking; infectious disease; neuropsychological assessment; subjective cognitive impairment.

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Figures

Figure 1.
Figure 1.
Bar graph demonstrating rates of subjective cognitive decline (SCD) in persons with HIV (PWH) and HIV− individuals.
Figure 2.
Figure 2.
Box and whisker plot showing the differences on time-based and event-based prospective memory (PM) tasks on the Cambridge Prospective Memory Test (CAMPROMPT) among persons with HIV (PWH) with subjective cognitive decline (SCD) and PWH without SCD. Prospective memory is defined as the ability to remember and carry out an intention in the future. *p<.05
See this image and copyright information in PMC

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