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. 2022 Oct 12;75(8):1442-1445.
doi: 10.1093/cid/ciac288.

Comparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore

M Premikha  1 , Calvin J Chiew  1 , Wycliffe E Wei  1 , Yee Sin Leo  2   3   4   5   6 , Benjamin Ong  1   4 , David Chien Lye  2   3   4   5 , Vernon J Lee  1   6 , Kelvin Bryan Tan  1   6
Affiliations

Comparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore

M Premikha et al. Clin Infect Dis. .

Abstract

Compared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29-2.46) and 1.62 (95% CI, 1.43-1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.42 (95% CI, 0.25-0.70) times less likely to develop severe disease.

Keywords: COVID-19; SARS-CoV-2; inactivated vaccine; mRNA vaccine; vaccines.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.