Tracking down tumor-specific T cells

James Reading¹, Kane Foster², Kroopa Joshi³, Benny Chain⁴

Affiliations

¹ Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
² Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
³ Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
⁴ Division of Infection and Immunity, University College London, London, UK. Electronic address: b.chain@ucl.ac.uk.

PMID: 35413268
DOI: 10.1016/j.ccell.2022.03.007

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Tracking down tumor-specific T cells

James Reading et al. Cancer Cell. 2022.

Free article

. 2022 Apr 11;40(4):351-353.

doi: 10.1016/j.ccell.2022.03.007.

Authors

James Reading¹, Kane Foster², Kroopa Joshi³, Benny Chain⁴

Affiliations

¹ Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
² Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
³ Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
⁴ Division of Infection and Immunity, University College London, London, UK. Electronic address: b.chain@ucl.ac.uk.

PMID: 35413268
DOI: 10.1016/j.ccell.2022.03.007

Abstract

Two papers published in this edition of Cancer Cell (Zheng et al., 2022 and Veatch et al., 2022) provide an elegant illustration of how single-cell sequencing can be used to define a molecular phenotype which identifies tumor-specific T cells.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Neoantigen-specific CD4⁺ T cells in human melanoma have diverse differentiation states and correlate with CD8⁺ T cell, macrophage, and B cell function.
Veatch JR, Lee SM, Shasha C, Singhi N, Szeto JL, Moshiri AS, Kim TS, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi SS, Hall ET, Byrd DR, Thompson JA, Pillarisetty VG, Duhen T, McGarry Houghton A, Newell E, Gottardo R, Riddell SR. Veatch JR, et al. Cancer Cell. 2022 Apr 11;40(4):393-409.e9. doi: 10.1016/j.ccell.2022.03.006. Cancer Cell. 2022. PMID: 35413271 Free PMC article.
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers.
Zheng C, Fass JN, Shih YP, Gunderson AJ, Sanjuan Silva N, Huang H, Bernard BM, Rajamanickam V, Slagel J, Bifulco CB, Piening B, Newell PHA, Hansen PD, Tran E. Zheng C, et al. Cancer Cell. 2022 Apr 11;40(4):410-423.e7. doi: 10.1016/j.ccell.2022.03.005. Cancer Cell. 2022. PMID: 35413272

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Tracking down tumor-specific T cells

Affiliations

Tracking down tumor-specific T cells

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical