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Comment
. 2022 Apr 11;40(4):356-358.
doi: 10.1016/j.ccell.2022.03.011.

Breaching B cell tolerance in the tumor microenvironment

Allyson C Banville  1 , Brad H Nelson  2
Affiliations
Free article
Comment

Breaching B cell tolerance in the tumor microenvironment

Allyson C Banville et al. Cancer Cell. .
Free article

Abstract

The immune system employs complex tolerance mechanisms in order to avoid harmful autoimmunity, yet autoantibodies are frequently observed in cancer. In a paper in Cell, Mazor et al. report that autoantibodies produced by tumor-infiltrating B cells in human ovarian cancer frequently recognize the self-protein matrix metalloproteinase 14 (MMP14) through two distinct mechanisms of tolerance disruption.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.
    Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z. Mazor RD, et al. Cell. 2022 Mar 31;185(7):1208-1222.e21. doi: 10.1016/j.cell.2022.02.012. Epub 2022 Mar 18. Cell. 2022. PMID: 35305314

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