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. 2022 Mar;19(1):49-51.
doi: 10.5114/kitp.2022.114557. Epub 2022 Mar 24.

Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax

Affiliations

Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax

Ismail Tombul et al. Kardiochir Torakochirurgia Pol. 2022 Mar.
No abstract available

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Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1
Figure 1
A – Sinus bluntness is seen on the right chest X-ray. B – Thorax computed tomography shows alveolar hemorrhage and pleural effusion
Figure 2
Figure 2
A – Appearance of pleural fluid drained by catheter thoracostomy. B – Chest X-ray shows lung expansion after the catheter thoracostomy treatment

References

    1. Shatzel JJ, Olson SR, Tao DL, McCarty OJT, Danilov AV, DeLoughery TG. Ibrutinib-associated bleeding: pathogenesis, management and risk reduction strategies. J Thromb Haemost. 2017;15:835–47. - PMC - PubMed
    1. Lipsky AH, Farooqui MZ, Tian X, Martyr S, Cullinane AM, Nghiem K, Sun C, Valdez J, Niemann CU, Herman SEM, Saba N, Soto S, Marti G, Uzel G, Holland SM, Lozier JN, Wiestner A. Incidence and risk factors of bleeding-related adverse events in patients with chronic lymphocytic leukemia treated with ibrutinib. Haematologica. 2015;100:1571–8. - PMC - PubMed
    1. Levade M, David E, Garcia C, Laurent PA, Cadot S, Michallet AS, Bordet JC, Tam C, Sié P, Ysebaert L, Payrastre B. Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions. Blood. 2014;124:3991–5. - PubMed
    1. Lehr A., Condos R. Spontaneous hemothorax in a patient on ibrutinib. Am J Respir Crit Care Med. 2020;201:A3124.
    1. von Hundelshausen P, Siess W. Bleeding by bruton tyrosine kinase-inhibitors: dependency on drug type and disease. Cancers. 2021;13:1103. - PMC - PubMed