Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 11;8(2):00672-2021.
doi: 10.1183/23120541.00672-2021. eCollection 2022 Apr.

Bilateral endobronchial valves treatment for severe emphysema

Nicolas Guibert  1   2 , Romane Fumat  1 , Marion Dupuis  1 , Matthieu Dusselier  3 , Florent Favard  3 , Valentin Heluain  1 , Siham Mallah  1 , Romain Barthes  1 , Yannick Simonneau  3 , Thomas Egenod  3
Affiliations

Bilateral endobronchial valves treatment for severe emphysema

Nicolas Guibert et al. ERJ Open Res. .

Abstract

Bilateral endobronchial valves treatment can lead to additional significant benefits in patients who respond to the first procedure and have a clear target lobe on both lungs but increases the rate of complications https://bit.ly/3J0mZ8h.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: N. Guibert reports receiving personal fees for participation on a data safety monitoring board or advisory board for PulmonX, outside the submitted work. Conflict of interest: R. Fumat has nothing to disclose. Conflict of interest: M. Dupuis has nothing to disclose. Conflict of interest: M. Dusselier has nothing to disclose. Conflict of interest: F. Favard has nothing to disclose. Conflict of interest: V. Heluain has nothing to disclose. Conflict of interest: S. Mallah has nothing to disclose. Conflict of interest: R. Barthes has nothing to disclose. Conflict of interest: Y. Simonneau has nothing to disclose. Conflict of interest: T. Egenod reports receiving personal fees for participation on a data safety monitoring board or advisory board for PulmonX, outside the submitted work.

Figures

FIGURE 1
FIGURE 1
a) Main outcomes after each procedure and combined outcomes. b) Computed tomography scan and c) perfusion tomoscintigraphy showing the example of a patient with an extremely heterogeneous emphysema who experienced dramatic improvements after both interventions: forced expiratory volume in 1 s (FEV1) increase by 73% after a first right lower lobe EBV treatment (460 mL to 800 mL) and 74% more after a subsequent left lower lobe treatment (800 mL to 1380 mL), after an overall 2950 mL residual volume (RV) decrease (7840 to 4890 mL). d) Changes in the main parameters: RV, FEV1, 6-min walking distance (6MWD) and BODE (body mass index, obstruction (FEV1), dyspnoea (modified Medical Research Council dyspnoea score (mMRC)), exercise capacity (6MWD)) score (median) after the first procedure (T1) and after contralateral treatment (T2). TLVR: target lung volume reduction; NA: not applicable.
See this image and copyright information in PMC

References

    1. Davey C, Zoumot Z, Jordan S, et al. . Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial. Lancet 2015; 386: 1066–1073. doi:10.1016/S0140-6736(15)60001-0 - DOI - PubMed
    1. Klooster K, ten Hacken NHT, Hartman JE, et al. . Endobronchial valves for emphysema without interlobar collateral ventilation. N Engl J Med 2015; 373: 2325–2335. doi:10.1056/NEJMoa1507807 - DOI - PubMed
    1. Valipour A, Slebos D-J, Herth F, et al. . Endobronchial valve therapy in patients with homogeneous emphysema. results from the IMPACT study. Am J Respir Crit Care Med 2016; 194: 1073–1082. doi:10.1164/rccm.201607-1383OC - DOI - PubMed
    1. Kemp SV, Slebos D-J, Kirk A, et al. . A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (TRANSFORM). Am J Respir Crit Care Med 2017; 196: 1535–1543. doi:10.1164/rccm.201707-1327OC - DOI - PubMed
    1. Labarca G, Uribe JP, Pacheco C, et al. . Bronchoscopic lung volume reduction with endobronchial zephyr valves for severe emphysema: a systematic review and meta-analysis. Respiration 2019; 98: 268–278. doi:10.1159/000499508 - DOI - PubMed

LinkOut - more resources