Neurofilament light chain: defining the analyte

Claire A Leckey^{1

2

3}, Henrik Zetterberg^{1

2

4

5

6}

Affiliations

¹ UK Dementia Research Institute at UCL, London, UK.
² Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
³ Centre for Translational Omics, UCL Great Ormond Street Institute of Child Health, London, UK.
⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
⁵ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
⁶ Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.

PMID: 35415606
PMCID: PMC8994106
DOI: 10.1093/braincomms/fcac070

Neurofilament light chain: defining the analyte

Claire A Leckey et al. Brain Commun. 2022.

. 2022 Mar 21;4(2):fcac070.

doi: 10.1093/braincomms/fcac070. eCollection 2022.

Authors

Claire A Leckey^{1

2

3}, Henrik Zetterberg^{1

2

4

5

6}

Affiliations

¹ UK Dementia Research Institute at UCL, London, UK.
² Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
³ Centre for Translational Omics, UCL Great Ormond Street Institute of Child Health, London, UK.
⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
⁵ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
⁶ Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.

PMID: 35415606
PMCID: PMC8994106
DOI: 10.1093/braincomms/fcac070

Abstract

This scientific commentary refers to 'A map of neurofilament light chain species in brain and cerebrospinal fluid and alterations in Alzheimer's disease' by Budelier et al. (https://doi.org/10.1093/braincomms/fcac045).

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Comment on

doi: 10.1093/braincomms/fcac045

References

1. Rosengren LE, Karlsson JE, Karlsson JO, Persson LI, Wikkelsø C. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament light protein in CSF. J Neurochem. 1996;67:2013–2018. - PubMed
1. Bridel C, van Wieringen WN, Zetterberg H, et al. . Diagnostic Value of cerebrospinal fluid neurofilament light protein in neurology: A systematic review and meta-analysis. JAMA Neurol. 2019;76:1035–1048. - PMC - PubMed
1. Malmeström C, Haghighi S, Rosengren L, Andersen O, Lycke J. Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS. Neurology. 2003;61:1720–1725. - PubMed
1. Abdulle S, Mellgren Å, Brew BJ, et al. . CSF neurofilament protein (NFL) – a marker of active HIV-related neurodegeneration. J Neurol. 2007;254:1026–1032. - PubMed
1. Zetterberg H, Hietala MA, Jonsson M, et al. . Neurochemical aftermath of amateur boxing. Arch Neurol. 2006;63:1277–1280. - PubMed

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Neurofilament light chain: defining the analyte

Affiliations

Neurofilament light chain: defining the analyte

Authors

Affiliations

Abstract

Comment on

References

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