Technical case report: intractable focal seizures related to bifrontal transmantle heterotopia subserving peculiar homotopic motor distribution treated by responsive neurostimulation therapy
- PMID: 35415805
- DOI: 10.1007/s00701-022-05193-y
Technical case report: intractable focal seizures related to bifrontal transmantle heterotopia subserving peculiar homotopic motor distribution treated by responsive neurostimulation therapy
Abstract
NeuroPace responsive neurostimulation (RNS®) therapy was used in a case of intractable focal epilepsy with bifrontal transmantle heterotopia subserving peculiar homotopic motor distribution in a 16-year-old, right-handed male with intractable seizures. Brain MRI demonstrated bifrontal transmantle heterotopia extending from the central sulcus to subjacent lateral ventricles along with polymicrogyria along the overlying cortex suspected to be the motor cortex. Functional MRI demonstrated homotopic distribution of finger and foot motor function (deeper) within the polymicrogyria. Invasive intracranial monitoring with depth electrodes and extraoperative brain mapping revealed eloquent cortical tissue which corresponded to the right leg and right shoulder motor function.
Keywords: Case report; Heterotopia; Intractable epilepsy; Responsive neurostimulation (RNS).
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
References
-
- Bartolini L, Kao A, Zachery A, Murnick JG, Gaillard WD (2017) Teaching NeuroImages: homotopic motor distribution on fMRI in closed-lip schizencephaly. Neurology 88(2):e24–e25 - DOI
-
- Chipaux M, Taussig D, Dorfmuller G et al (2019) SEEG-guided radiofrequency thermocoagulation of epileptic foci in the paediatric population: Feasibility, safety and efficacy. Seizure 70:63–70 - DOI
-
- Jobst BC, Kapur R, Barkley GL et al (2017) Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 58(6):1005–1014 - DOI
-
- Mirandola L, Mai RF, Francione S, Pelliccia V, Gozzo F, Sartori I et al (2017) Stereo-EEG: diagnostic and therapeutic tool for periventricular nodular heterotopia epilepsies. Epilepsia 58:1962–1971 - DOI
-
- Morrell MJ, Group RNSSiES (2011) Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurol 77(13):1295–1304
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources