DC1s shield Tpex cells to bolster PD-1 blockade

David G Brooks¹, Pamela S Ohashi²

Affiliations

¹ Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: dbrooks@uhnresearch.ca.
² Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: pam.ohashi@uhnresearch.ca.

PMID: 35417669
DOI: 10.1016/j.immuni.2022.03.017

Free article

Comment

DC1s shield Tpex cells to bolster PD-1 blockade

David G Brooks et al. Immunity. 2022.

Free article

. 2022 Apr 12;55(4):577-579.

doi: 10.1016/j.immuni.2022.03.017.

Authors

David G Brooks¹, Pamela S Ohashi²

Affiliations

¹ Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: dbrooks@uhnresearch.ca.
² Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: pam.ohashi@uhnresearch.ca.

PMID: 35417669
DOI: 10.1016/j.immuni.2022.03.017

Abstract

Responsiveness to PD-1 blockade depends on a cell subset known as Tpex cells, but how these cells are sustained is less understood. In this issue of Immunity, Dähling et al. show how dendritic cells form a niche for Tpex preservation.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.
Dähling S, Mansilla AM, Knöpper K, Grafen A, Utzschneider DT, Ugur M, Whitney PG, Bachem A, Arampatzi P, Imdahl F, Kaisho T, Zehn D, Klauschen F, Garbi N, Kallies A, Saliba AE, Gasteiger G, Bedoui S, Kastenmüller W. Dähling S, et al. Immunity. 2022 Apr 12;55(4):656-670.e8. doi: 10.1016/j.immuni.2022.03.006. Epub 2022 Apr 1. Immunity. 2022. PMID: 35366396

Publication types

Actions

MeSH terms

Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

DC1s shield Tpex cells to bolster PD-1 blockade

Affiliations

DC1s shield Tpex cells to bolster PD-1 blockade

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources