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Comment
. 2022 Apr 12;55(4):580-582.
doi: 10.1016/j.immuni.2022.03.010.

RIP(K)ing away immunotherapy resistance

Mira A Patel  1 , Sohail F Tavazoie  2
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Comment

RIP(K)ing away immunotherapy resistance

Mira A Patel et al. Immunity. .
Free article

Abstract

Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo et al. identify RIPK1 as an interferon-stimulated gene with potent effects on cell extrinsic and intrinsic immunotherapy resistance.

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Conflict of interest statement

Declaration of interests S.F.T. is a co-founder, shareholder, and member of the scientific advisory board of Inspirna.

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